Wise n' Shine: NFL picks, MLB predictions and NCAAF best bets for Thursday, September 21

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Caleb Wilfinger


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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.

Welcome to another wonderful Wednesday of sports, Pickswise Nation. Thursday Night Football returns in the NFL, plus we have a full slate of MLB games today including a ton of afternoon action, so let’s get straight to making your next bet better!

About Last Night

Incredible 9-0 run on MLB prop picks!
With no NFL action on Tuesday, our MLB team stayed hot with another solid day. Our YRFI/NRFI expert Caleb Wilfinger was on the ball once again, going 2-0 to bring YRFI/NRFI run to 33-15. On top of that, our incredible MLB props run continued with another 2-0 day, taking us to a 9-0 streak and a 22-5 record in our last 27 prop picks!

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Today’s Slate

TNF in the Bay Area
Things could get ugly on Thursday night when the Giants head to San Francisco as heavy underdogs against the 49ers, who look like the best team in the NFL at the moment. San Francisco is coming off a win over the Rams while New York rallied from 21 points down to knock off the Arizona Cardinals last Sunday. Be sure to check out our Giants vs 49ers picks.

More MLB to enjoy
There is a full solid 9-game slate of baseball coming our way today, starting at 1:10 pm ET with the Angels vs Rays game, while Mets vs Phillies and Orioles vs Guardians is on FOX at 7:05 pm ET. Check out all of today’s MLB picks.

Best Bet of the Day

NFL: San Francisco 49ers -10 (-110) over New York Giants
8:15 pm ET, Amazon Prime

The New York Giants earned a memorable 21-point comeback against the Cardinals last Sunday but the euphoria of that victory is likely to be shortlived as they make the trip to San Francisco to take on the 49ers. The Giants were down 28-7 at one point in that game against Arizona before fighting to a 31-28 success, but star running back Saquon Barkley was lost to injury. The win followed a 40-0 humiliation at the hands of the Cowboys in Week 1 and although last Sunday’s success was the perfect remedy to that defeat, it still showed New York’s struggles as they barely made it past a Cardinals team expected to be among the worst in the NFL this season. Read our full Giants vs 49ers predictions.

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Today’s MLB YRFI/NRFI best bets are ready to read, and don’t miss our Giants vs 49ers Same Game Parlay at massive +1325 odds! NFL fans can also check out our updated NFL power rankings and our expert’s NFL Futures update, including a best bet for Offensive Rookie of the Year. Prop Holliday has also provided his NFL player prop picks for the Giants vs 49ers matchup on Thursday Night Football.

Head over to the Analysis tab for even more great sports betting content as it arrives throughout the day.

Stat of the Day

The New York Giants haven’t won on Thursday Night Football since they beat Washington in 2015.

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