NFL Week 4 5-Leg Parlay: Best Picks for Sunday's Games at +1917 odds
Week 4 of the NFL season kicked off on Thursday with Cleveland’s thrilling win over AFC North rival Pittsburgh, and now it’s time to focus on a full Sunday slate. It is headlined by Colts vs Commanders in London, Jaguars vs Bengals, Rams vs Eagles, Chiefs vs Raiders, Broncos vs 49ers and Lions vs Panthers on Sunday Night Football.
Below is my mega parlay, and also be sure to check out all of our NFL picks.
Bears ML (-180)
Bills -6.5 (-122)
Eagles +3.5 (-105)
Chiefs -4.5 (-105)
49ers -2.5 (-115)
NFL parlay odds: +1917
Chicago Bears ML over New York Jets (-180)
Tyson Bagent is scheduled to start under center for Chicago. How much confidence must Ben Johnson have in Bagent is the Bears’ head coach is will to sit Case Keenum after what Keenum did in Week 3 against Philadelphia? The answer, of course, is a lot! And if Keenum can run that offense pretty much to perfection, Bagent should be able to do the same – especially against the Jets. New York is 1-2 with nothing more than a win over lowly Tennessee. I’m not thriller about the prospect of giving 3.5 points when Caleb Williams isn’t on the field, but the Bears should win.
Buffalo Bills -6.5 over New England Patriots (-122)
The Patriots have scored no more than 13 points in four of their last five games dating back to last season’s playoffs, with their highest output coming in a Week 2 win over Pittsburgh (20). The Bills’ defense allowed 31 points in each of their first two wins over Houston and Detroit, but the Chargers managed to score only one touchdown even though Buffalo turned the ball over five times. New England ranks 27th in offensive success rate at 40.1, so don’t be surprised if it gets shut down by the home team on Sunday afternoon.
Philadelphia Eagles +3.5 over Los Angeles Rams (-105)
Philadelphia has won four straight in the head-to-head series dating back to 2023. That includes a huge 33-26 victory last season in the Eagles erased a 26-7 third-quarter deficit. The Rams are expected to get top receiver Puka Nacua back from a groin injury after missing the last two games, but Aaron Donald is out. They are 2-7 against the spread in their last nine games away from home, so at the very least you have to like the Eagles chances of covering on Sunday. Head coach Nick Sirianni’s squad has not been anything special so far, but it still comes in with a 2-1 record compared to L.A.’s 1-2 mark.
Kansas City Chiefs -4.5 over Las Vegas Raiders (-105)
Despite a perfect record, I’m not quite ready to push my chips into the center of the table with Las Vegas. Veteran QB Kirk Cousins is playing solid football, but this is a tough matchup for the 38-year-old. The Chiefs rank #6 in league against the pass, third in yards per pass attempt allowed and second in QB rating allowed. Kansas City is actually looking like a well-oiled machine on both sides of the ball these days. The offense could be better than ever now that it features a star running back, reigning Super Bowl MVP Kenneth Walker III. Walker has already rushed for 360 yards and has scored four total touchdowns this season. Offensive tackle Josh Simmons (back) is still out, but backup Kahlil Benson has played well in Simmons’ absence.
San Francisco 49ers -2.5 over Denver Broncos (-115)
Perhaps no team in the NFL has looked better than San Francisco through three weeks. Head coach Kyle Shanahan's outfit is 3-0 with victories over the Rams, Dolphins and Cardinals by a combined 48 points. QB Brock Purdy is playing at an MVP level, showcasing mistake-free football (one turnover this season) while distributing the ball impressively to his stable of playmakers and completing 72.3 percent of his attempts. Purdy has thrown nine touchdown passes. Although Nick Bosa (calf) is sidelined, the Niners’ defense is deep enough to compensate for that absence. Fred Warner is back and has already forced two fumbles in 2026. Denver is 2-1 but should be 1-2 after the officials botched the end of last week's game against the Rams.
