Manchester City vs Southampton Prediction, Odds and Picks for Saturday, 04/25/26

The Premier League title is back within Manchester City’s reach after their 2-1 win over leaders Arsenal on Sunday and the odds suggest that won’t be the only piece of silverware the Citizens add to their EFL Trophy crown this season. They are strong favourites to lift the FA Cup for the 3rd time under Pep Guardiola, and he, more than anyone, would love them to do so after consecutive final defeats to Manchester United and Crystal Palace in the competition. The form book makes good reading for City fans, with their last 4 games including 3-0 and 4-0 routs of Chelsea and Liverpool, plus a couple of wins over Arsenal, but Guardiola knows those opponents inside-out and will face an entirely different challenge in Saturday’s semifinal. 

On paper, Championship club Southampton should be demolished by the Premier League title favourites. However, that was precisely the case in their quarterfinal against Arsenal, only for the Saints to run out deserved 2-1 winners. Tonda Eckert’s team has followed up that shock victory with 4 straight league wins to put themselves in the race for automatic promotion — a simply unfathomable outcome given their lowly position when the young German took over. The Saints are playing brilliant football without fear and may keep things closer than some expect at Wembley, especially with City’s focus now turning to a Premier League title race that they really should have been out of a long time ago.

Man City vs Southampton prediction: Southampton +1.5 (+114) available at time of publishing. Playable at that number.

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