MLB Best Bets

Welcome to the home of our MLB best bets. Our expert handicappers analyze all of the latest team news, statistics, form, and trends to bring to you our MLB best bets. For the remainder of our MLB picks, including a pick for each game of the MLB season, head over to our MLB Picks and MLB Predictions pages.

Our MLB best bets will be released at the latest at 11 am EST once all lines have become available with sportsbooks.

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9:40 PM ET
Today
Colorado Rockies
Arizona Diamondbacks
Rockies
Diamondbacks
Game Totals PickBest Bet
Over 9.0(-115)

The Arizona offense is rolling right now. The Diamondbacks scored 23 total runs in their 3-game sweep over the Giants, and enter this Thursday night matchup against the Rockies averaging 7.0 runs per game over their last 6 contests. Going up against Colorado starting pitcher Tomoyuki Sugano, the D-Backs should be able to keep the offensive momentum going. Opponents own a strong .794 OPS against Sugano, and he has a 6.46 ERA through 3 starts in May. With the way the D-Backs bats are rolling right now, Sugano figures to have his hands full. Plus, Arizona is facing Sugano for the 2nd time is as many starts for the 36-year-old right-hander. Last week, Sugano allowed just 2 runs over 5.0 innings against the D-Backs, but he still allowed 7 hits and had just a single strikeout. I expect the Diamondbacks to be better this time around.

Eduwardo Rodriguez will toe the rubber for the home team. The veteran left-hander has had a rough tenure in the desert, as he owns a 4.51 ERA in 48 starts with the Diamondbacks. His numbers this season aren’t bad, but he is still a tough pitcher to trust at this point in time. His current ERA of 2.53 is nearly 2 full runs lower than his xERA of 4.51, and he allowed 9 hits and 3 earned runs over 5.1 innings of work last week against the Rockies. Neither of these starting pitchers rack up a ton of strikeouts, and both have had their fair share of struggles lately. All in all, both offenses appear to be at an advantage in this NL West matchup.

Rockies vs Diamondbacks prediction: Over 9 (-115) available at time of publishing. Playable to -125.

MLB Best Bets
58.3%
Win %
21Wins
15Losses
0Pushes
Percentage only includes Wins and Losses

What Are Our MLB Best Bets

At Pickswise our expert handicappers spend hours analyzing each match of the MLB season, delving into the latest MLB statistics, team news, travel, schedule, weather, trends to name just a few angles we cover and consider.

With a typical MLB regular season containing a total of 2,430 games, researching this many games in the required depth is an exhaustive task. Our experts take care of all of that, so you don’t have to.

With a large number of games each day throughout the 2026 season and up to 15 matches on any given day (or sometimes more if there are doubleheaders), being selective in your wagers is key in trying to secure a long-term profit. That’s where our confidence ratings and MLB best bets come into play.

Our MLB Best bets are exactly what you would expect them to be, our top picks for today’s slate of games, with our reasoning and analysis for each MLB Best Bet alongside. 

How Do I Know What Your MLB Best Bets Are For Today?

Our MLB best bets for today will appear right here, on our MLB best bets page.

Across our site, our expert handicappers provide the best free MLB predictions and match previews for every game of the MLB season and include a confidence rating for each of our MLB predictions.

The rating system runs from one to three stars, the more stars, the more confidence in the pick, with the most confident MLB Picks highlighted here on our MLB best bets page.

As soon as the sportsbooks release the odds and lines for today’s MLB games our expert handicappers will be combining these with their research to find today’s MLB best bets. 

Where Should I Wager On Your MLB Best Bets Today?

MLB is one of the most popular sports that sports bettors place wagers on and as such, most online sportsbooks will offer competitive prices about a plethora of markets on each game.

While we preview every game of the MLB season from Opening Day through to the World Series, betting on every game is not recommended, with a betting strategy very much needed to see you turn a profit over the season.

A big part of this strategy is making sure you are wagering on our MLB Predictions at the best possible odds. With each sportsbook pricing up markets differently, be sure to shop around to make sure you are on our MLB Best Bets at the best odds available.

All of our MLB picks are accompanied by the best available odds and which online sportsbooks are offering them, as well as our detailed reasoning for the pick.

If you don’t yet have an account with one of the sportsbooks listed as having the best odds, why not check out our Sportsbook Bonuses Page to see the latest promo codes available in your state and get off to a flyer with a great sign up bonus. To see our thoughts on the leading online sportsbooks, check out our Online Sportsbook Reviews Page right here.

Baseball Betting – Best Baseball Bets Today 

Baseball betting can be tricky with so many games played each day and across the season – 2,340 in just the regular season alone! There are also many different ways that you can wager on baseball betting, from traditional markets like the Money Line, Run Line, and Runs Totals, to MLB Prop Bets such as player runs, hits, and strikeouts, or Team Props such as team runs or innings betting. Our baseball best bets page is the best place to start when looking at your baseball betting today. Here our expert handicappers post their best baseball bets on today’s slate with full analysis, reasoning, and odds.  Check out our MLB Predictions and MLB Picks pages for all of our other baseball betting previews and picks.

MLB Lock Of The Day – MLB Lock Picks Today 

Looking for MLB Lock Picks today? Well, you’re in the right place. At Pickswise, our MLB Lock picks will be right here on our MLB Best Bets page every day of the regular season and into the MLB playoffs. With 2,430 regular-season games played alone in an MLB season, and numerous games played on any given day, it’s not wise to bet on them all. What you’ll find here is our MLB expert handicappers’ MLB Lock Of The Day, our most confident pick. Each MLB Lock Pick will be accompanied by a full match preview and analysis including why we have this as being a lock. You can also check out how our MLB Lock picks have fared across the season, with our 2026 MLB Best Bets Record displayed at the top of this page.

Be sure to check out our MLB Picks and MLB Predictions for all of our other MLB bets on today’s games.