MLB Best Bets

Welcome to the home of our MLB best bets. Our expert handicappers analyze all of the latest team news, statistics, form, and trends to bring to you our MLB best bets. For the remainder of our MLB picks, including a pick for each game of the MLB season, head over to our MLB Picks and Predictions page.

Our MLB best bets will be released at the latest at 11 am EST once all lines have become available with sportsbooks.


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Money Line, CIN Reds @ ARI Diamondbacks


The Cincinnati Reds have gotten off to a hot start this season, and will look to keep it rolling here as they wrap up their three-game series with the Arizona Diamondbacks. The Reds will start Jose De Leon, who went from pretty much out of the league to surprisingly making Cincy’s rotation due to injuries. He was surprisingly solid in his first start, but even after giving up only two runs in five innings, his career ERA through 34.2 innings is still 7.79. I think he’s going to come crashing down to earth here. Before last week he hadn’t started a big league game since 2016, and there’s a reason why.

Arizona will start Luke Weaver, who is coming off a tough 2020 but was excellent in 2019. In his first start of 2021 he gave up three runs in 5.2 innings, but that was at Coors Field and he only gave up four baserunners the whole time. so I think he just got a bit unlucky. Cincinnati’s offense has looked good, but it feels fluky with a bunch of no-names overachieving so far. Take Arizona.

2021 MLB Best Bets Record
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MLB Best Bets

What Are Our MLB Best Bets

At Pickswise our expert handicappers spend hours analyzing each match of the MLB season, delving into the latest MLB statistics, team news, travel, schedule, weather, trends to name just a few angles we cover and consider.

With a typical MLB regular season containing a total of 2,430 games, researching this many games in the required depth is an exhaustive task. Our experts take care of all of that, so you don’t have to.

With a large number of games each day throughout the 2021 season and up to 15 matches on any given day, being selective in your wagers is key in trying to secure a long-term profit. That’s where our confidence ratings and MLB best bets come into play.

Our MLB Best bets are exactly what you would expect them to be, our top picks for today’s slate of games, with our reasoning and analysis for each MLB Best Bet alongside. 

How Do I Know What Your MLB Best Bets Are For Today?

Our MLB best bets for today will appear right here, on our MLB best bets page.

Across our site, our expert handicappers provide the best free MLB predictions and match previews for every game of the MLB season and include a confidence rating for each of our MLB predictions.

The rating system runs from one to three stars, the more stars, the more confidence in the pick, with the most confident MLB Picks highlighted here on our MLB best bets page.

As soon as the sportsbooks release the odds and lines for today’s MLB games our expert handicappers will be combining these with their research to find today’s MLB best bets. 

Where Should I Wager On Your MLB Best Bets Today?

MLB is one of the most popular sports that sports bettors place wagers on and as such, most online sportsbooks will offer competitive prices about a plethora of markets on each game.

While we preview every game of the MLB season from Opening night through to the World Series, betting on every game is not recommended, with a betting strategy very much needed to see you turn a profit over the season.

A big part of this strategy is making sure you are wagering on our MLB Predictions at the best possible odds. With each sportsbook pricing up markets differently, be sure to shop around to make sure you are on our MLB Best Bets at the best odds

All of our MLB picks are accompanied by the best available odds and which online sportsbooks are offering them, as well as our detailed reasoning for the pick.

If you don’t yet have an account with one of the sportsbooks listed as having the best odds, why not check out our Sportsbook Bonuses Page to see the latest promo codes available in your state and get off to a flyer with a great sign up bonus. To see our thoughts on the leading online sportsbooks, check out our Online Sportsbook Reviews Page right here.

Baseball Betting – Best Baseball Bets Today 

Baseball betting can be tricky with so many games played each day and across the season – 2,340 in just the regular season alone! There are also many different ways that you can wager on baseball betting, from traditional markets like the Money Line, Run Line, and Runs Totals, to MLB Prop Bets such as player runs, hits, and strikeouts, or Team Props such as team runs or innings betting. Our baseball best bets page is the best place to start when looking at your baseball betting today. Here our expert handicappers post their best baseball bets on today’s slate with full analysis, reasoning, and odds.  Check out our MLB Predictions and Picks page for all of our other baseball betting previews and picks.

MLB Lock Of The Day – MLB Lock Picks Today 

Looking for MLB Lock Picks today? Well, you’re in the right place. At Pickswise, our MLB Lock picks will be right here on our MLB Best Bets page every day of the regular season and into the MLB playoffs. With 2,430 regular-season games played alone in an MLB season, and numerous games played on any given day, it’s not wise to bet on them all. What you’ll find here is our MLB expert handicappers’ MLB Lock Of The Day, our most confident pick. Each MLB Lock Pick will be accompanied by a full match preview and analysis including why we have this as being a lock. You can also check out how our MLB Lock picks have fared across the season, with our 2021 MLB Best Bets Record displayed on the top of the page.

Be sure to check out our MLB Picks and MLB Predictions for all of our other MLB bets on today’s games.