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College Football Best Bets

Here you will find our college football best bets for every week of the 2025-26 season. Our cappers have a wealth of experience and expertise in college football bets, data analytics and statistical modelling, to bring you the best NCAAF bets all season long.

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Money Line (1)Point Spread (1)

Experts

Pickswise Experts (2)

12:00 PM ET

Tomorrow

Connecticut

Boston College

Money Line PickBest Bet

Connecticut Win(+105)

Reasoning

Bill O’Brien and the Boston College Eagles are struggling. Sitting at 1-5, the Eagles have yet to beat an FBS opponent, as their only win of the season was in Week 1 against Fordham. Most recently, BC scored just 17 combined points against Pitt and Clemson in back-to-back weeks. Now, the Eagles will host a regional non-conference opponent in the UConn Huskies, who come into this contest at 4-2 following a bye week and figure to be way more locked-in on this game than the Eagles.

The Huskies have played one of the worst strength-of-schedules in the country, but it’s not like Boston College’s is much better. The Eagles are outside the top-90 in that aspect and have lost to teams like Michigan State, Stanford and Cal – all of whom are right near UConn in my power ratings. In fact, I have UConn above Boston College in my power ratings even when accounting for home-field advantage – of which the Eagles don’t have much.

Jim Mora’s Huskies lean more to the pass than they do the run in most cases, and it makes sense given how well QB Joe Fagnano has played. The 6’4” senior has been in college for what has felt like an eternity due to COVID eligibility and injuries – dating back to 2019 when he started with Maine – and it shows in his play. He has thrown 11 touchdowns this year with 0 interceptions and just 3 turnover-worthy plays, while completing just over 67% of his passes. Via his shoulder, the Huskies are 23rd in yards per play against FBS opponents this season, in addition to top-15 in PPA per pass and passing downs PPA since Week 3. Moreover, UConn is 3rd nationally in turnover margin and 9th in penalties per game against FBS opponents.

Averaging more than 4.5 points per quality drive in the last 5 weeks, expect a pumped-up UConn offense to be able to move the ball up and down the field against what figures to be a lifeless Boston College defense. For reference, over the last month or so, the Eagles are outside the top 110 in most of the defensive metrics I evaluate every week, including points allowed per quality drive and PPA per play allowed. Going one step further, the Eagles are 126th in passing downs PPA and 129th in PPA per pass in that time. When you combine those poor passing numbers with BC’s 128th-ranked havoc rate, it’s hard not to see a path to success for the Huskies. I will trust the numbers here and take UConn, who should be vastly more motivated in this game than BC.

UConn vs Boston College prediction: UConn Huskies ML (+105) at the time of publishing. Playable to -110.

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Sam Avellone

7:45 PM ET

Tomorrow

Missouri

Auburn

Point Spread PickBest Bet

Auburn +1.5(-110)

Reasoning

We’ve got the Tigers vs Tigers in an interesting spot for both Missouri and Auburn. For starters, Mizzou has yet to play a single road game this season and has had a relatively easy schedule prior to the Alabama matchup – its lone loss. For Auburn, the hosting Tigers are set to face-off against a ranked opponent for the 4h-consecutive week, losing the previous matchups by 10 points or less. Auburn has had one of the most difficult schedules in the country through 6 weeks and has been battle tested, while Mizzou’s toughest opponent outside of Bama was a 3-3 South Carolina squad – a matchup in which the Tigers failed to cover the spread.

Narratives aside, the Auburn defense has been solid all year, even through the gauntlet of a schedule. The hosts rank 29th in yards per game allowed, 18th in defensive success rate and have been particularly excellent against the run, ranking 3rd in EPA/rush – something that should serve well matched-up against an elite RB like Ahmad Hardy. On the other side of the ball, the run game has been solid for Auburn, ranking 15th in EPA/rush, while QB Jackson Arnold has taken care of the ball with 0 INTs through 6 games. This is a tough place to win on the road, I’ve got Auburn covering at home.

Missouri vs Auburn prediction: Auburn Tigers +1.5 (-110) available at time of publishing. Playable at that number or better.

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BET +1.5 NOW WITH

Ryan Bunnell

NCAAF Best Bets

38.2%

Win %

13Wins

21Losses

0Pushes

Percentage only includes Wins and Losses

What Are Our College Football Best Bets

At Pickswise our team of expert college football handicappers conducts extensive research across all of the best college football action throughout the season and into the postseason, with the sole aim of bringing you the most informed and best free college football bets around.

Alongside our expert analysis, our handicappers will post their prediction for every game including picks on the over/under market, Against the Spread, and Moneyline picks. Each of our selections across Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least.

In addition to our confidence ratings, college football bettors in particular – with the sheer number of games each weekend, like to know what our most confident selections are across the slate. This is where our College Football Best Bets page comes to the fore, here we detail just that, our most confident selections, our NCAAF best bets this weekend.

College Football Best Bets Today

Find all of our best college football bets today, right here on our College Football Best Bets page.

There are countless ways in which you can wager on a college football game and with hundreds of games each week in a typical season, being selective in your wagering is arguably the most important aspect in achieving long-term betting success on college ball.

Covering every game in the required detail is a long process, and then filtering down your picks into those top selections, your best bets is a difficult task. Fortunately, here at Pickswise, we lean on industry-leading analysis and decades of wagering experience to bring you the top NCAAF best bets this week for free. Not only do we break down every match, but we also highlight our best college football bets today right here, each week, so be sure to check back for those best bets across the college football slate.

The College Football Best Bets page works perfectly with our College Football Predictions page where you can find all of our game previews, in addition to our best bets here, to combine for a comprehensive view of today’s college football games.

What Is The Best Site To Wager On Your College Football Best Bets Today

There are many ways in which you can wager on our college football best bets today, with all major sportsbooks all vying to offer the most competitive odds. As with any sports wagering you do, you must compare odds and markets to seek out the best value with all of our NCAAF best bets.

With all of our College Football Picks, and College Football Parlays, we post the best odds, and the sportsbook offers those odds next to our selections.

With the volatility of sports odds, these can change quickly, so be sure to check before you wager. An extra point on the spread can be the difference between winning and losing, and why bet the money line at +250 when you can get +350 elsewhere?

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Best College Football Bets This Weekend

With so many college football games scheduled across the conferences each weekend, you simply can’t bet on them all. Our college football best bets this weekend are just that, our best bets across this weekend’s college football games.

All of our best bets are posted during the week to allow you to take in and break down our analysis and best bets, before deciding whether you agree, and want to place a bet.

Posting our best college football bets ahead of time for this weekend also gives you more time to shop the odds, and in all likelihood, ensure you get the best odds, on our best bets.

Best Bets Against The Spread College Football

The most popular college football bet is betting against the spread (ATS). Against the spread betting isn’t about picking a winner of the game, it’s about picking the team who will cover the spread, a line set by sportsbooks. Let’s say you bet your money that Team A covers the spread (wins by a certain amount of points), Michigan -8.5 for example. Or that Team B will cover the spread (keep the game closer than oddsmakers expect), Penn State +8.5. If Michigan beat Penn State 30-27, then Penn State covers the spread, and underdog backers are cashing tickets with +8.5 on Penn State. Whereas if Michigan wins 30-20, more than 8.5 they cover the spread and favorite backers are cashing tickets.

When Do You Post Your NCAAF Best Bets For This Weekend

We post all of our NCAAF Best Bets at least a day before the scheduled college football match. We wait until this point to allow our expert handicappers to consider every angle such as injury updates, press conferences and team news, as well as extensive statistical research. Our NCAAF Best Bets are exactly what they say on the tin. With so many NCAAF games played each weekend, we have a confidence rating on all of our NCAAF Picks, with 3 stars being the most confident, and then we further narrow down our three-star plays into our NCAAF Best Bets. These will typically be posted on a Thursday or Friday ahead of the weekend’s schedules. Check out this week’s NCAAF Best Bets right here on the College Football Best Bets page.