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College Football Best Bets

Here you will find our college football best bets for every week of the 2025-26 season. Our cappers have a wealth of experience and expertise in college football bets, data analytics and statistical modelling, to bring you the best NCAAF bets all season long.

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Point Spread (2)

Experts

Pickswise Experts (2)

8:00 PM ETFri Aug 29

Point Spread Pick

Georgia Tech -4.0(-110)Georgia Tech @ Colorado

Reasoning

The hype train of the Colorado Buffaloes will have a new look in 2025, as Deion Sanders’ squad must adjust to life without Shedeur Sanders and Travis Hunter. Entering Week 1 at home as underdogs, Colorado could have tremendous growing pains in the 2025 campaign after replacing its QB, top-4 receiving targets and a trio of offensive lineman. The Buffaloes will be led by veteran liberty transfer Kaidon Salter at QB, though they return just 3 starters total from what was an electric offense. While Salter is no Joe Schmoe, I expect the passing game to struggle a bit against a veteran Georgia Tech secondary that ranks top-40 in returning production. The defense for Colorado, however, presented serious problems last year and will be leaned on more this time around without the star power on offense. Not to forget, Coach Prime had an array of health problems over the offseason and his squad enters the new year with a ton of questions marks.

On the contrary, the Georgia Tech program is building something in head coach Brent Key’s third full season at the helm. While the Buffaloes are a mystery with a bevy of new transfer players in what begins a new era for coach Sanders, we know almost exactly what to expect out of the Yellow Jackets. QB Haynes King returns for another year while 1,000-yard rusher Jamal Haynes is back as well to lead the rushing attack. Not to forget, Colorado is without their star cornerback, top pass rusher, both safeties and both linebackers from a year ago defensively. Really the only concern for the Yellow Jackets entering 2025 is the offensive line, though Brent Key has built a reputation developing lineman and I’ll trust his experience at the position. Give King time in the backfield, and look out. I’ll take the experience of Georgia Tech’s roster to come out on top and cover the spread in this spot.

Georgia Tech vs Colorado prediction: Yellow Jackets -4 (-110) available at time of publishing. Playable at that number or better.

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BET -3.5 NOW WITH

Ryan Bunnell

3:30 PM ETSat Aug 30

Point Spread Pick

South Dakota Win +15.5(-110)South Dakota @ Iowa State

Reasoning

Last week, we faded the Cyclones when they were in Dublin, squaring off for Farmageddon against hated rival Kansas State. In the college football season kickoff of two ranked sides, ISU delivered the goods in what was a thrilling 24-21 win. Some takeaways to consider, K-State if one watched the game, actually controlled most of the game flow until things opened up late in the second-half, but even then the Wildcats matched them in stride. It was a sloppy affair with a lot of variance involved, the Cyclones were the benefactors of that and emerged with the W. Add in the emotional nature of the win and the fact that Cy-Hawk is up next, this has a sandwich game feel to it which makes the Coyotes dangerous.

A little bit about South Dakota, they are #5 in the Coaches Polls for FCS teams in the pre-season and are not a team to come in flat against or look past, ISU, included. The spot screams trap and with all the mayhem that ensures in Week One, there is at least one FCS-FBS upset, generally speaking. If we were to scan the list for potential candidates, this would have to be near the top, if the not at the top. Make no mistake, South Dakota will see this as an opportunity and if the Coyotes show up while the Clones are flat-footed, not only do we cover here, but an upset is very much possible.

South Dakota vs. Iowa State prediction: South Dakota (+15.5) available at time of publishing. Playable to +15.

BET +15.5 NOW WITH

Napier Montgomery

What Are Our College Football Best Bets

At Pickswise our team of expert college football handicappers conducts extensive research across all of the best college football action throughout the season and into the postseason, with the sole aim of bringing you the most informed and best free college football bets around.

Alongside our expert analysis, our handicappers will post their prediction for every game including picks on the over/under market, Against the Spread, and Moneyline picks. Each of our selections across Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least.

In addition to our confidence ratings, college football bettors in particular – with the sheer number of games each weekend, like to know what our most confident selections are across the slate. This is where our College Football Best Bets page comes to the fore, here we detail just that, our most confident selections, our NCAAF best bets this weekend.

College Football Best Bets Today

Find all of our best college football bets today, right here on our College Football Best Bets page.

There are countless ways in which you can wager on a college football game and with hundreds of games each week in a typical season, being selective in your wagering is arguably the most important aspect in achieving long-term betting success on college ball.

Covering every game in the required detail is a long process, and then filtering down your picks into those top selections, your best bets is a difficult task. Fortunately, here at Pickswise, we lean on industry-leading analysis and decades of wagering experience to bring you the top NCAAF best bets this week for free. Not only do we break down every match, but we also highlight our best college football bets today right here, each week, so be sure to check back for those best bets across the college football slate.

The College Football Best Bets page works perfectly with our College Football Predictions page where you can find all of our game previews, in addition to our best bets here, to combine for a comprehensive view of today’s college football games.

What Is The Best Site To Wager On Your College Football Best Bets Today

There are many ways in which you can wager on our college football best bets today, with all major sportsbooks all vying to offer the most competitive odds. As with any sports wagering you do, you must compare odds and markets to seek out the best value with all of our NCAAF best bets.

With all of our College Football Picks, and College Football Parlays, we post the best odds, and the sportsbook offers those odds next to our selections.

With the volatility of sports odds, these can change quickly, so be sure to check before you wager. An extra point on the spread can be the difference between winning and losing, and why bet the money line at +250 when you can get +350 elsewhere?

Unsure where is best to place your college football best bets? Or looking to make the most of new account offers and promo codes? Be sure to check out our Online Sportsbook Reviews for the lowdown on all of the top online sportsbooks in your state, and find the best promo codes on our Bonuses Page.

Best College Football Bets This Weekend

With so many college football games scheduled across the conferences each weekend, you simply can’t bet on them all. Our college football best bets this weekend are just that, our best bets across this weekend’s college football games.

All of our best bets are posted during the week to allow you to take in and break down our analysis and best bets, before deciding whether you agree, and want to place a bet.

Posting our best college football bets ahead of time for this weekend also gives you more time to shop the odds, and in all likelihood, ensure you get the best odds, on our best bets.

Best Bets Against The Spread College Football

The most popular college football bet is betting against the spread (ATS). Against the spread betting isn’t about picking a winner of the game, it’s about picking the team who will cover the spread, a line set by sportsbooks. Let’s say you bet your money that Team A covers the spread (wins by a certain amount of points), Michigan -8.5 for example. Or that Team B will cover the spread (keep the game closer than oddsmakers expect), Penn State +8.5. If Michigan beat Penn State 30-27, then Penn State covers the spread, and underdog backers are cashing tickets with +8.5 on Penn State. Whereas if Michigan wins 30-20, more than 8.5 they cover the spread and favorite backers are cashing tickets.

When Do You Post Your NCAAF Best Bets For This Weekend

We post all of our NCAAF Best Bets at least a day before the scheduled college football match. We wait until this point to allow our expert handicappers to consider every angle such as injury updates, press conferences and team news, as well as extensive statistical research. Our NCAAF Best Bets are exactly what they say on the tin. With so many NCAAF games played each weekend, we have a confidence rating on all of our NCAAF Picks, with 3 stars being the most confident, and then we further narrow down our three-star plays into our NCAAF Best Bets. These will typically be posted on a Thursday or Friday ahead of the weekend’s schedules. Check out this week’s NCAAF Best Bets right here on the College Football Best Bets page.