Baltimore Orioles vs New York Yankees Prediction, Odds and Picks for Today, 09/27/25

The New York Yankees have tied the Toronto Blue Jays for the divisional lead with just 2 games remaining in the regular season. This is one of many divisional and wild card races going on in the final days leading up to the playoffs, and I expect the Yankees to grab a win over Baltimore Saturday. The Orioles have had a down season given preseason expectations and are set to finish last in the AL East after a 91-win season last year. Tomoyuki Sugano is set to close out his rookie season. The 35-year-old has a 4.54 ERA in 152.2 innings entering this matchup, and he has allowed 9 home runs within his last 5 starts alone.

Cam Schlittler is also set to close out the regular season of his rookie campaign for the Yankees, but the 24-year-old has found more success this season than his counterpart. While in just 66 innings of work spanning 13 starts, Schlittler has posted a 3.27 ERA with 75 strikeouts in that span. His command can be shaky with 30 walks issued, but his talent is obvious, and I am a fan of his upside moving forward. Look for the Yankees to win this game by multiple runs.

New York Yankees vs Baltimore Orioles prediction: Yankees -1.5 (-110) available at time of publishing. Playable to -115 odds.