Boston Red Sox vs Tampa Bay Rays Prediction, Odds and Picks for Today, 09/21/25

I favor the Boston Red Sox over the Tampa Bay Rays as the teams face off on Sunday. Connelly Early is set to make his 3rd career start for the Red Sox in this game, and his first 2 outings went very well. Both starts were against the Athletics, interestingly enough, and those starts combined for 10.1 innings of 1-run ball with 18 strikeouts recorded to just 1 walk issued. The southpaw hurler tore up the minor leagues this season and is now contributing meaningful innings for a young Red Sox team looking to make postseason noise.

Joe Boyle is scheduled as the Rays starting pitcher for this matchup. Boyle enters play with a 4.64 ERA across his first 42.2 innings of work. It is a small sample for the talented right-hander, but he often struggles to find command of the strike zone. When his command falters his performance tends to spiral, and Boyle can be a wild card as a starter. Pitching in Tampa Bay’s minor league park can amplify those concerns as well.

Tampa Bay Rays vs Boston Red Sox prediction: Red Sox ML (-130) available at time of publishing. Playable to -135 odds.