Chicago Cubs vs Miami Marlins Prediction, Odds and Picks for Today, 05/21/25

The Chicago Cubs and Miami Marlins will play the rubber game of their series when they meet again on Wednesday afternoon in Miami. Miami opened with an 8-7 victory on Monday before getting blown out 14-1 on Tuesday. My Cubs vs Marlins pick is Over 8.5, as Wednesday’s contest figures to be another high-scoring affair. And why not? Chicago leads all of Major League Baseball in runs scored, as it has for basically the entire year. The visitors will need all the runs they can get in this one since Cade Horton is toeing the rubber and can’t be expected to keep the Marlins’ bats quiet. Horton has made just 2 MLB appearances (both this month) and is saddled with a 6.00 ERA through 9.0 innings of work. He has been rocked for 3 home runs during his very brief career.

Miami is countering with Max Meyer, who has also struggled to keep baseballs in the ballparks. Meyer has surrendered 8 dingers on the season, including 4 in his 3 May starts. The right-hander is 3-4 with a 4.47 ERA and 1.33 WHIP through 50.1 innings. Meyer has decent stuff, but he is generally all over the place — either outside or the zone or too many meatballs right down the middle. Needless to say, Chicago is a team that can capitalize on those kinds of mistakes. Ian Happ is 2-for-3 lifetime against Meyer with 1 home run and Pete Crow-Armstrong is 1-for-2 with a homer. Fortunately for the Fish, they have scored 8 runs or more in 2 of their last 5 outings. Give me the over.

Cubs vs Marlins prediction: Over 8.5 (-120) available at time of publishing. Playable at that number.

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