Chicago Cubs vs Milwaukee Brewers Prediction, Odds and NLDS Game 2 Picks for Today, 10/06/25

Game 1 of the National League Divisional Series between the Chicago Cubs and Milwaukee Brewers resulted in a 9-3 Milwaukee win. The Brewers will look to follow up on that strong start to the series with another win at home as the teams square off Monday evening. Aaron Ashby is the scheduled starter for the Brewers in Game 2, as the southpaw pitcher looks to deliver another scoreless outing. Ashby recorded 4 outs in the Game 1 win and Milwaukee likes how he matches up with the top 0f the Cubs’ lineup. The Brewers are likely to mix and match their pitchers throughout the rest of the game, attempting to limit the advantages this Cubs lineup holds. That could work well for Milwaukee given its depth and available arms.

Shota Imanaga has a lot of pressure on his left arm tonight as he looks to even the series at 1 win apiece. The lefty starter had a very solid season with a 3.73 ERA in 144.2 innings of work, and he gives the Cubs one of their better options on the mound in a time that they need him. Milwaukee presents a difficult matchup for opposing pitchers, however, and the lefty is not in his best form of the season right now. His first postseason appearance resulted in multiple walks and a home run in 4.0 innings of work, and Imanaga allowed 15 home runs in his last 9 regular-season starts with at least 1 surrendered in each outing. Look for Milwaukee to grab an early lead and use its bullpen to secure another win.

Cubs vs Brewers prediction: Milwaukee ML (-125) available at time of publishing. Playable at that number.

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