Chicago White Sox vs Milwaukee Brewers Prediction, Odds and Picks for Today, 03/28/26

The Chicago White Sox were bounced 14-2 in Thursday’s opener, which is not exactly what the team envisioned, as the team is expected to be slightly better than recent seasons. That’s a tough start. The White Sox won just 60 games in 2025, and they were just 21-27. RHP Sean Burke takes the ball trying to get things on track properly. He was 4-11 with a 4.29 ERA with a 1.45 WHIP last season, and was just 0-6 with a 4.74 ERA across 57 IP with 11 homers allowed and a .258 opponent batting average in eight road starts and four relief appearances.

For the Brewers, RHP Chad Patrick made his MLB debut with a 3-8 record, 3.53 ERA and 1.28 WHIP across 23 starts and four relief appearances, striking out 127 batters in just 119 2/3 IP. He was solid working at American Family Field, going 2-4 with a 2.94 ERA with a .235 opponent batting average with 7 homers allowed in 67 1/3 IP in 12 starts at home with 3 relief appearances. As such, let’s back the Brewers to get the job done at home, and we’ll lay the run and a half at plus-money rather than pay up on the money line.

White Sox vs Brewers prediction: Brewers -1.5 (+110) at time of publishing. Playable to -110.