Chicago White Sox vs San Diego Padres Prediction, Odds and Picks for Today, 05/02/26

The Chicago White Sox will look to keep things rolling after winning four straight, including an 8-2 win over the San Diego Padres last night. Meanwhile, San Diego has dropped three in a row and will try to get back on track behind Michael King, who is 3-1 with a 2.41 ERA and a 1.04 WHIP through six starts this season. For the White Sox, Sean Burke will look to build off his last start, entering at 1-2 with a 3.21 ERA and a 1.04 WHIP.

The biggest edge for the White Sox right now is at the plate. Over their last 13 games, they’re hitting .266 with 24 home runs and averaging 5.9 runs per game. For the Padres, they’re batting .223 with 12 home runs and averaging 4.3 runs per game over their last 12 matchups. As far as the bullpen goes, they’re not far apart with the White Sox holding a 4.90 ERA and the Padres sit at 4.09. While San Diego holds the advantage on the mound with King and a slightly stronger bullpen, it’s hard to back a team that isn’t producing consistently at the plate. With the White Sox swinging hotter bats, I think Burke can deliver another solid performance on the mound today and the White Sox will steal another one on the road against a Padres team that is struggling offensively. 

White Sox vs Padres prediction: White Sox ML (+160) at the time of publishing. Playable up to +140.