Cleveland Guardians vs Arizona Diamondbacks Prediction, Odds and Picks for Tuesday, 08/19/25

The Cleveland Guardians picked up a 3-1 victory in the interleague series opener Monday night against the Arizona Diamondbacks, as RHP Gavin Williams pitched well in 5 1/3 scoreless innings, while the offense did just enough. 1B CJ Kayfus surprised with a solo homer, finishing 2-for-3 in the victory. 2B Brayan Rocchio also hit the seats, going 1-for-3 with the blast and two RBI. Cleveland has fallen off the pace in the American League Central, after applying some pressure to the Detroit Tigers last week. The Guardians are 20-26 in interleague play, too, and if they miss the playoffs, the NL is a big reason why.

For the Diamondbacks, they’ve dropped four in a row, including the final three games in Denver against the lowly Colorado Rockies. They turn to LHP Eduardo Rodriguez to get the job done on Tuesday. He picked up the last victory for Arizona, an 8-2 win in the series opener Thursday in Colorado. The Guardians are just 15-21 against left-handed starting pitchers this season, so let’s back the Diamondbacks to get the job done, evening the interleague series, setting up a rubber match for Wednesday.

Guardians vs Diamondbacks predictions: Diamondbacks ML (-115) at time of publishing. Playable to -125.

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