Cleveland Guardians vs Boston Red Sox Prediction, Odds and Picks for Today, 09/01/25

The Cleveland Guardians open a 3-game series on the road against the Boston Red Sox on Monday night at Fenway Park. Cleveland won two of three games over the weekend against the Seattle Mariners, and it keeps hanging around in the American League wild-card picture, just four games back of the Mariners, and 6.5 games back of the Red Sox, for a postseason spot. Cleveland has won 4 of the past 5 games since being shut out 3 times in a row from Aug. 23-25. The under is 3-1-1 in the past 5 games, and 6-3-1 across the past 10 outings.

For the Red Sox, they picked up a 5-2 win Sunday against the Pittsburgh Pirates, salvaging the interleague series finale behind RHP Lucas Giolito. The Red Sox are a respectable 8-3 in the past 11 games, and they turn to RHP Brayan Bello to keep it going. He is 10-6 with a 2.99 ERA and 1.21 WHIP across 23 starts and one relief appearance, while going 4-2 with a 2.45 ERA across his past seven outings. He also has a 1.07 WHIP across that span. Roll with the Red Sox in this Labor Day matinee game, as they look to get off on the right foot in this series opener.

Guardians vs Red Sox prediction: Red Sox ML (-150) available at time of publishing. Playable to -170.

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