Cleveland Guardians vs Detroit Tigers Prediction, Odds and Picks for Today, 09/16/25

I favor the under on the posted game total for Tuesday’s matchup between the Cleveland Guardians and the Detroit Tigers. Cleveland enters this game 3 games back from the final wild card spot in the American League, and they will need to rattle off some wins in order to regain positioning. Detroit holds the 2nd best record in the AL and is looking to hold on to their first-round bye. Joey Cantillo is set to start this game for the Guardians, and he enters this game in terrific form. His last start resulted in 8 scoreless innings against the Royals and his 3 prior starts combined for 16.2 innings of 3-run ball.

Casey Mize is scheduled as Detroit’s starting pitcher for this matchup, and the former first overall pick has put together a solid season for the Tigers in 2025. Mize has tossed 131.2 innings while maintaining a 3.83 ERA along the way. His first 2 starts this month were against both New York teams, and despite the tough playoff level competition, Mize was able to deliver with 11 innings of 3-run ball for his squad.

Detroit Tigers vs Cleveland Guardians prediction: Under 8 (-105) available at time of publishing. Playable at that price.