Cleveland Guardians vs San Francisco Giants Prediction, Odds and Picks for Tuesday, 06/17/25

The Cleveland Guardians limp into the Bay Area after getting pounded over the weekend by the Seattle Mariners in a 3-game sweep at T-Mobile Park in the Pacific Northwest. The Guardians were not only swept, but they were also outscored 17-5 — including a 6-0 loss on Sunday afternoon. The Guardians have scored 4 or fewer runs in 12 of the past 13 games, with the exception being an 11-run outburst against the Cincinnati Reds last Wednesday. They send RHP Slade Cecconi to the mound Tuesday, and he was on the unfortunate end of a 1-0 loss to the Reds last Tuesday. Cleveland has been shut out in both of his past 2 starts, too.

For the San Francisco Giants, they made a trade for DH Rafael Devers over the weekend. He was hitting .272 with 15 homers, 58 RBI and a .905 OPS with the Boston Red Sox. His HR count ranked 15th in the majors, the RBI were tied for third, while he is 12th in OPS. It will be a big boost for the San Francisco offense. He tore up Cleveland pitching in a series at Progressive Field earlier this season, going 5-for-13 with a double, a homer and 2 RBIs in 3 games April 26-28. Look for the Giants to get off to a big start with Devers, LHP Robbie Ray and company. Cleveland is 10-14 in interleague play and just 5-13 against LHPs this season.

Guardians vs Giants prediction: San Francisco ML (-160) available at time of publishing. Playable to -180.

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