Cleveland Guardians vs St. Louis Cardinals Prediction, Odds and Picks for Today, 04/14/26

The Cleveland Guardians are looking to pickup back-to-back wins over the St. Louis Cardinals when they meet on Tuesday night at Busch Stadium. Cleveland took the series opener by a score of 9-3 on Monday night. That game went over the total, but Tuesday’s matchup could be a different story. The pitching matchup in this one pits Cleveland’s Joey Cantillo against St. Louis’ Michael McGreevy, and both starters are off to strong starts this season.

Cantillo has allowed just 11 hits and 4 earned runs through 3 starts to begin the 2026 campaign. He’s also already racked up 20 strikeouts through 14.2 innings of work. The Cardinals offense has been fairly boom-or-bust so far this season, and they’ve scored just 10 total runs over their last 4 games. Cantillo has what it takes to hold the Redbirds in check. McGreevy is also in a groove early on, as he’s allowed just 11 hits and 4 earned runs in 3 starts and 16.2 inning. His strikeout numbers aren’t as prominent, but the Guardians don’t possess an overwhelmingly daunting lineup. After a high-scoring game in the opener, look to the under here.

Guardians vs Cardinals prediction: Under 8.5 (-120) available at time of publishing. Playable at that number.