Cleveland Guardians vs Tampa Bay Rays Prediction, Odds and Picks for Today, 09/04/25

The Cleveland Guardians head down to the Suncoast to battle the Tampa Bay Rays in the opener of a 4-game series. Cleveland comes in with a little pep in its step after pounding the Boston Red Sox 8-1 Wednesday, salvaging the series finale. The Guardians are a respectable 5-3 in the past 8 games, while scoring at least 4 runs in 6 of the past 7 contests. Despite the win on Wednesday, Cleveland is still a dismal 1-7 in the past 8 games on the road. The Guardians turn to LHP Logan Allen for the series opener.

The Rays are a solid 23-18 against left-handed starting pitching this season, and the Rays are 37-33 in their temporary home at Steinbrenner Field. The Rays have fired up to one game over .500, and they’re back in the thick of the race of a wild-card spot in the American League. Tampa Bay has won 6 in a row, and 9 of the past 11 games since Aug. 22. Tampa Bay turns to RHP Ryan Pepiot to get the job done in the series opener, and the Rays are 4-1 in his past 5 starts. At home, he is 6-4 with a 3.25 ERA and 1.10 WHIP with a .220 batting average allowed across 83 IP in 14 starts. Back the Rays to stay hot in the series opener.

Guardians vs Rays prediction: Rays ML (-150) at time of publishing. Playable to -160.

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