Colorado Rockies vs San Francisco Giants Prediction, Odds and Picks for Today, 09/26/25

Trevor McDonald pitched 142.1 innings at the AAA level in the Giants organization this season, posting a 5.31 ERA and 5.53 FIP along the way. The Giants are out of postseason contention and are now giving McDonald major-league work. The fact that the Giants are favored with a -240 price on the ML given my first 2 sentences is remarkable but goes to show just how bad the 2025 version of the Colorado Rockies have been. Colorado is 43-116 entering this final series of the season, and there is no shot I am picking a side given the lopsided pricing. Instead, I will focus on the total as either starter is liable for a poor outing.

German Marquez is 3-15 this season with a 6.49 ERA and just 82 strikeouts in 122.0 innings of work. His 1.70 WHIP is resulting in never-ending base traffic and his inability to generate a third strike is leading to trouble for the veteran right-hander. Pitching for Colorado will automatically make your numbers appear worse than you are, but it is clear that Marquez is also not the pitcher he once was.

Rockies vs Giants prediction: Over 8 (-115) available at time of publishing. Playable at that number.

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