Colorado Rockies vs Seattle Mariners Prediction, Odds and Picks for Today, 09/25/25

The season can’t come to a conclusion soon enough for the Colorado Rockies, as they have 115 losses, and they’re just 12-35 in interleague play. Meanwhile, the Seattle Mariners clinched the American League West Division with a win Wednesday night, and they’re just one game off the pace for the best record in the American League, and home-field advantage through the playoffs. Seattle still has plenty left to play for, while Colorado is just playing out the string.

The Rockies hand the ball to RHP Bradley Blalock, and he has been atrocious this season. He is 2-5, which isn’t that bad, but in 11 starts and two relief appearances across 55 IP, he has a terrible 9.16 ERA and 1.82 WHIP. He has an 8.64 ERA across the past seven starts, and he is 0-2 with a 7.89 ERA and 1.48 WHIP with five homers surrendered across 21 2/3 IP in four day starts and one relief appearance. The Mariners are undecided on their starter for Thursday, but does it really matter? Blalock is horrible, Cal Raleigh is red-hot at the plate, and Seattle should be able to pile up the runs yet again.

Rockies vs Mariners prediction: Mariners -1.5 (+100) available at time of publishing. Playable to -110.

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