Houston Astros vs Cleveland Guardians Prediction, Odds and Picks for Saturday, 06/07/25

The Houston Astros and Cleveland Guardians play the middle contest of a three-game series at Progressive Field. The Astros won the opener 4-2 on Friday night, and now they turn to, arguably, their best pitcher in RHP Hunter Brown to clinch the series victory. Brown has posted an 8-3 record with a sparkling 1.83 ERA and 0.91 WHIP across 73 2/3 IP in 12 starts with one complete game this season. He also has 84 strikeouts which ranks him 11th in the majors. On the road, he has been slightly more human, posting a 4-2 record and 2.51 ERA, but teams are still hitting just .206 against him in road games, while he has issued just eight walks with 46 strikeouts across 43 IP.

The Guardians have RHP Gavin Williams going, and he has been sharp at home. He is 4-2 with a 3.38 ERA across 34 2/3 IP in seven starts at Progressive Field, but those numbers still pale in comparison to the road splits and overall numbers of his counterpart. The Astros should get the job done in a low-scoring game, if you’re interested in a same-game parlay opportunity. Houston has cashed the under in 4 of the past 5 games, with the team allowing just 7 total runs, or 1.4 runs per game, during the span.

Astros vs Guardians predictions: Astros ML (-115) at time of publishing. Playable to -130.

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