Houston Astros vs Los Angeles Angels Prediction, Odds and Picks for Today, 09/28/25

The Houston Astros are the most recent team to have been eliminated from playoff contention and there will be only one AL West team in the postseason as a result. Not only did the Mariners surpass Houston with their trade deadline additions, but the Guardians surged back with their unique roster and the Tigers held on for the final spot. As a result, Houston will go ahead and give Lance McCullers Jr. a shot at one final MLB starts for 2025. McCullers Jr. is someone who has battled numerous injuries in previous seasons and this season has tossed just 52.1 innings. In that sample he has a 6.71 ERA with 38 walks issued and 8 home runs allowed. Los Angeles should score early and often in this spot.

The Angels are starting Sam Aldegheri in this spot for his fourth appearance and 2nd start of the season. His first 3 appearances have totaled 9 innings with 8 earned runs allowed, issuing 7 free passes with 13 hits surrendered. Aldegheri made 24 minor-league starts this season totaling 133.1 innings with a 3.78 ERA and 4.36 FIP. He profiles as a backend starter and someone that opposing major league lineups can take advantage of. Look for runs in this season finale.

Astros vs Angels prediction: Over 9.5 (-105) available at time of publishing. Playable at that price.

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