Houston Astros vs Seattle Mariners Prediction, Odds and Picks for Today, 04/12/26

It’s been a tough recent stretch for the Houston Astros, who have lost 6 straight games – including being swept by the Colorado Rockies. Saturday’s loss was a brutal one, as Houston jumped out to a 7-2 lead through 4 innings just to give up 5 in the 5th and 1 in the 9th to lose 8-7. Meanwhile, the M’s survived Luis Castillo’s 10-hit, 7-earned run performance to win their 2nd game in a row after a stretch of 5 straight losses. 

Logan Gilbert will take the hill for Seattle on Sunday, as he looks for his first win of the season after his first quality start on Monday. His first 2 outings were forgettable – 8 ER in 10.2 IP vs CLE and NYY – but the 2-run, 5-strikeout performance against the Rangers showed some promise. This Astros lineup has plenty of experience against Gilbert, and while he’s been solid against Houston in his career on the surface, Jose Altuve, Yordan Alvarez and Chrisian Walker have had their fair share of success against the right-hander.

For Houston, it looks like Cody Bolton will start. He isn’t exactly an innings-eater having thrown just 7.1 innings in 2 appearances thus far, which is slightly concerning for Houston’s over-worked bullpen. That said, he’s been somewhat solid on the mound, surrendering just 3 earned runs and 6 hits with 10 strikeouts and 3 walks. 

Considering the pitching matchup and the taxed bullpens ahead of this game, I’m surprised to see a total below 8. These teams will play again tomorrow, so there’s no getaway day to consider here, either. I’ll ride the hot bats and take the over in this AL West showdown despite Seattle’s park being very pitcher-friendly. 

Astros vs Mariners prediction: Over 7.5 (-115) at the time of publishing. Playable to -120. 

You can bet on our Astros vs Mariners pick with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first $10+ wager is a winner!