Houston Astros vs The Athletics Prediction, Odds and Picks for Today, 09/24/25

The Houston Astros have dropped four straight games to fumble away the American League West Division lead, and if the Seattle Mariners win Wednesday, or the Astros lost, the division title goes to the Pacific Northwest. Heading into the weekend, the Astros were tied for the division lead, so it’s a stunning turn of developments. With the division, and a postseason spot, on the line, Houston managed just three total hits in the 5-1 series opening loss to the A’s, as the Astros just couldn’t solve LHP Jeffery Springs. Houston is just 4-7 in 11 tries against the A’s, and they’ve dropped six in a row against them. If Houston cannot win the division, and it misses the playoffs, the A’s are mostly responsible.

The Astros turn to RHP Hunter Brown to get the job done, and keep his team alive. He was on the losing end of a 5-1 setback July 16 to the A’s in Houston, but Brown has a 2.30 ERA and 1.01 WHIP overall in 180 1/3 IP in 30 starts, and he has a 1.64 ERA across his past seven outings. On the flip side, RHP Luis Severino has a dreadful 1-9 mark, 6.51 ERA, 1.61 WHIP and 10 homers allowed in 76 IP across 14 starts at home. The pitching scales are tipped heavily in Houston’s favor, and the time is now for the Astros to deliver.

Astros vs Athletics prediction: Astros ML (-150) available at time of publishing. Playable to -175.

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