Los Angeles Angels vs Milwaukee Brewers Prediction, Odds and Picks for Today, 09/16/25

I expect the Milwaukee Brewers to win their matchup with the Los Angeles Angels on Tuesday evening by multiple runs. Freddy Peralta entered his last start against the Texas Rangers in about as good of form as a pitcher can have but was knocked around for 5 earned runs in that outing. His prior 6 starts had combined for just 1 earned run allowed total, and I expect him to rebound nicely Tuesday as he looks to regain form. On the season as a whole, Peralta holds a 2.69 ERA with 185 Ks and 16 wins recorded across 163.2 innings of work. He now faces an Angel lineup that has been striking out at an alarming rate. Fire up Peralta props and start him in fantasy with confidence.

Caden Dana is set to start this game for the Angels, and as you can tell he is the lesser of today’s starters by default. Dana has talent in his own right, and is someone I am interested to see develop, but in his 5th career outing today against a tough Milwaukee lineup, I am not looking to bet on him. Dana is set to face a Brewers lineup that displays plate discipline, power, and speed, a trifecta of skills that have earned them the best record in baseball so far. Look for Milwaukee to produce offensively and provide Peralta with run support.

Los Angeles Angels vs Milwaukee Brewers prediction: Brewers -1.5 (-120) available at time of publishing. Playable to -125 odds.