Los Angeles Angels vs Seattle Mariners Prediction, Odds and Picks for Today, 09/11/25

The Los Angeles Angels head north to face the Seattle Mariners for the first contest of a 4-game series. The Angels are well out of the postseason picture, but the Mariners are still playing for something. Seattle currently occupies the final wild-card spot in the American League. However, the Angels will be doing their best to play spoiler in the Pacific Northwest, beginning with a start from RHP Jose Soriano. He has so-so numbers overall, but the splits paint a different picture. His troubles have been at home, while he is an all-star like 8-2 with a 2.47 ERA and 1.19 WHIP across 87.1 IP in 14 road starts, while teams are hitting 35 points lower against him than in Anaheim.

On the flip side, Seattle’s Bryce Miller has struggled everywhere. He is a dismal 4-5 with a 5.53 ERA and 1.40 WHIP across 70 IP in 14 outings, while going just 2-2 with a 6.88 ERA in his past 7 starts across 35.1 IP. He has served up 6 homers at T-Mobile Park in 29.2 IP, and he has a 1.45 WHIP with a .257 opponent batting average. The Halos are a strong play as moderate underdogs behind a good road pitcher, while facing a guy who has been extremely shaky. This should be a costly loss for the M’s, and a nice payday for bettors.

Angels vs Mariners prediction: Los Angeles ML (+145) at time of publishing. Playable to +130.

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