Minnesota Twins vs Cleveland Guardians Prediction, Odds and Picks for Today, 05/01/25

The Minnesota Twins wrap up a 4-game series against the divisional rival Cleveland Guardians at Progressive Field on Thursday. So far, it hasn’t been a great stay for the Twins in Ohio. Minnesota routed Cleveland 11-1 in the series opener behind RHP Bailey Ober, but the Guardians have scratched out low-scoring wins in the past 2 days. Cleveland won 2-1 behind RHP Tanner Bibee on Tuesday while posting a 4-2 victory in Wednesday’s game, spoiling a quality start by the red-hot RHP Pablo Lopez. The Guardians erupted for 4 runs in the bottom of the 7th inning to flip the script.

After winning 4 in a row and 6 of 7, the Twins have now dropped 2 straight. The Twins have allowed 4 or fewer runs in 9 straight games, including just 8 runs allowed in the past 5 outings. The Under is 4-1 in that span. For Cleveland, the 2 Under results in the past 2 days have been a welcome sign, as the pitching staff was terrorized for 31 runs in a three-game span from April 26-28. The offense is good for just 22 runs in the past 8 games, so the play here is the Under, especially at even-money.

Twins vs Guardians prediction: Under 9 (+100) available at time of publishing. Playable to -115.

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