Philadelphia Phillies vs Arizona Diamondbacks Prediction, Odds and Picks for Today, 09/21/25

We have a very interesting matchup between the Philadelphia Phillies and Arizona Diamondbacks this Sunday afternoon that is worth tuning into. Philadelphia enters this game with a 92-63 record which is good for the best in their division and likely to earn them a first-round bye. Arizona enters this game having sold several key pieces of their team at the trade deadline, yet just 2 games back from the final wild card spot in the National League. The Diamondbacks would need help from both the Mets and Reds to make the postseason, but a win today would go a long way to helping their cause.

I favor the Phillies in this matchup, however, as I believe they hold the advantage across the board in this spot. Ranger Suarez enters this game with a 2.84 ERA in his 149 innings of work, including quality starts in each of his last 3 starts and 5 of his last 6 outings. Eduardo Rodriguez, on the other hand, has allowed 4 or more earned runs in 4 of his last 8 starts and has a 5.12 ERA in his 142.1 innings this season. Rodriguez is also tasked with facing the tougher lineup and I am fonder of the Phillies bullpen.

Philadelphia Phillies vs Arizona Diamondbacks prediction: Phillies ML (-130) available at time of publishing. Playable to -135 odds.