Philadelphia Phillies vs Miami Marlins Prediction, Odds and Picks for Today, 09/06/25

I expect the Philadelphia Phillies to grab a win over the Miami Marlins as they face off Saturday afternoon in Miami. The Phillies are starting left-hander Jesus Luzardo who is set to make his 29th start of the season for the Phillies. It has been a successful debut season for Luzardo as a member of the Phillies following several years spent in the Marlins organization. Luzardo has faced this Miami lineup twice so far this season, but I still expect a strong start from him and view him as my preferred starter in this game.

Sandy Alcantara has tossed 27 innings with just 5 earned runs allowed across his last 4 starts combined, entering this game in the best form of his season. That being said, it has still been hard to trust Sandy in 2025 with his inconsistent performance and tendency to have a blow-up start. Even with his strong stretch of pitching recently, Alcantara’s season-long ERA is still an undesirable 5.66 mark. Look for the Phillies to win this game.

Miami Marlins vs Philadelphia Phillies prediction: Phillies ML (-160) available at time of publishing. Playable at that price.

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