Pittsburgh Pirates vs St. Louis Cardinals Prediction, Odds and Picks for Today, 08/27/25

In this game, we will see the Pittsburgh Pirates take on the St. Louis Cardinals. On the mound, we have Carmen Mlodzinski of the Pirates and Sonny Gray of the Cardinals. Mlodzinski has been moved to the bullpen, but has since improved his play. This month, he has pitched 14.2 innings, giving up only 7 hits and 3 earned runs. He has also faced the Cardinals earlier this season, where he gave up 2 runs in 4.2 innings. While these numbers are encouraging, the Cardinals have scored 10 runs over the past 2 days. Additionally, Mlodzinski has only pitched 3 innings in 2 of his last 6 appearances. This means that they will be relying on a Pirates bullpen that has a 4.14 ERA on the season. This is good news for a Cardinals team that is batting .212 but have still managed to average 4.5 runs per game over the past 6 games.

For the Cardinals, Gray will take the mound. Gray started the season in good form but has given up 3 or more runs in 5 of his last 7 starts. He also gave up 4 runs in 6.1 innings to the Pirates earlier this year. With these numbers, it may be a difficult outing for Gray as the Pirates are batting .298 over the past 6 games. The Pirates are also on a winning streak, as they have won 6 of their last 8 games. Outside of Gray, the Cardinals’ bullpen has been struggling in some of their recent games. I have a feeling that we may see some struggling pitchers on both sides of the ball in this one. Therefore, this leads me to believe that the over is the best play on Wednesday.

Pirates vs Cardinals prediction: Over 7.5 (+100) available at time of publishing. Playable at that number.

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