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US Open Predictions: Tennis Picks & Best Bets for Day Four – The end of the road for Victoria Azarenka?

US Open Predictions: Tennis Picks & Best Bets for Day Four – The end of the road for Victoria Azarenka?

Ricky Dimon
Ricky DimonAuthor
UpdatedAug 21, 2026
Reading time3 min

Second-round competition at the US Open gets underway on Wednesday, August 27, when Carlos Alcaraz, Novak Djokovic, Taylor Fritz, Ben Shelton, Aryna Sabalenka and Jessica Pegula are among those taking the court. I am 5-1 over the past 2 days and would be 6-0 if Matteo Arnaldi had not squandered a 2-set lead on Tuesday, so let’s keep the momentum going! Here are my US Open best bets for the Day 4 schedule.

US Open best bet: Anastasia Pavlyuchenkova ML over Victoria Azarenka (-130)

Odds available at bet365 at time of publishing.

Victoria Azarenka’s days of being a major title contender are long gone. The 36-year-old has done next to nothing at slams in 2025, losing in the Australian Open 1st round, the Roland Garros 2nd round and the Wimbledon 1st round. Azarenka is 10-11 overall this season, including 5-6 on outdoor hard courts. She has been plagued by various injuries in recent seasons and took a medical timeout for an apparent hip problem during her 7-6(0), 6-3 first-round victory over Hina Inoue. Meanwhile, Anastasia Pavlyuchenkova advanced to the Wimbledon 4th round earlier this summer and is coming off an impressive victory over Dayana Yastremska in round 1 of the US Open.

US Open prediction: Benjamin Bonzi ML over Marcos Giron (+100)

Odds available at bet365 at time of publishing.

Benjamin Bonzi won the most memorable match of the US Open so far. It would take too long to delve into all of the drama right here, but rest assured it was a wild one against Daniil Medvedev on Sunday night. Long story short (very short): Bonzi probably should have won in straight sets but ended up coming back from a break down in 5th to prevail 6-3, 7-5, 6-7(5), 0-6, 6-4 in 3 hours and 45 minutes. The Frenchman gets a much-needed 2 full days off, so he should be good to go for Wednesday’s match against Marcos Giron. The American also required 5 sets in his opening contest, an unspectacular win over clay-court specialist Mariano Navone. That does not inspire any confidence in Giron – nor does his 5-match losing streak going into New York.

If you want the best odds on our Pavlyuchenkova and Bonzi US Open best bets, make sure you use bet365. New users can click here to sign up now and they’ll receive $200 in bonus bets INSTANTLY when they make their first $5 wager — win or lose!

US Open pick: Eliot Spizzirri +3.5 games over Luciano Darderi  (-120)

Odds available at BetMGM at time of publishing.

I don’t even care that Luciano Darderi actually won a hard-court match in Winston-Salem last week and another one in the US Open 1st round. The Italian is still basically an automatic fade every time he plays on this surface. He is a hopeless 5-20 on hard courts (4-16 outdoors) dating back to the start of 2024. Eliot Spizzirri is more than capable of capitalizing on this golden opportunity. The American wild card clearly likes this tournament. He defeated Joao Fonseca to qualify for the main draw last summer and opened this fortnight with a straight-set victory over an in-form Stefan Dostanic. With home-court advantage and the surface edge, Spizzirri really should win this one outright.

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