San Diego Padres vs Chicago White Sox Prediction, Odds and Picks for Today, 09/19/25

I expect the San Diego Padres to defeat the Chicago White Sox by multiple runs Friday evening. Dylan Cease has not quote had the season he hoped for, entering this matchup with a 4.59 ERA, but his team is positioned for a playoff run and he figures to play a large role in how far they go. With that type of opportunity, mistakes can be forgotten if he is able to put together a strong run of pitching. He has delivered solid starts against the Rockies in his last 2 outings, and now he gets his former team with a weak lineup in the Chicago White Sox.

Davis Martin is set to start this game for Chicago, marking his 25th appearance of the season. Martin has perhaps exceeded expectations this season with the rest of the White Sox pitching staff imploding, but he is still not an arm I am overly confident in backing. Martin faces the tougher of today’s lineups in this game and the bullpen behind him does not instill much confidence either.

Padres vs White Sox prediction: San Diego Padres -1.5 (+100) available at time of publishing. Playable at that price.

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