San Diego Padres vs Colorado Rockies Prediction, Odds and Picks for Today, 09/06/25

While not a game I am rushing to bet, I do expect the San Diego Padres to win by multiple runs over the Colorado Rockies this Saturday evening. The posted game total for this game is set at 12, and it makes sense given the weaknesses that both starting pitchers have. Luckily for Randy Vasquez he is tasked with facing this weak Rockies lineup instead of the potent and deep Padres lineup that the Rockies have to deal with. Vasquez is by no means a starting pitcher I often trust, but he has produced a solid 3.96 ERA this season across 111.1 meaningful innings for the Padres.

McCade Brown is set to start this game for the Rockies, marking his 3rd career MLB start. The 6’6″ right-hander has allowed 16 base runners and 7 earned runs in his first 2 starts spanning a combined 7.2 innings against the Pirates and Cubs. His command was off in both outings, allowing 3 walks in each start, and now he has to face a San Diego lineup that typically employs quality plate discipline.

San Diego Padres vs Colorado Rockies prediction: Padres -1.5 (-135) available at time of publishing. Playable at that price.