San Diego Padres vs Seattle Mariners Prediction, Odds and Picks for Today, 08/27/25
Padres vs Mariners Pickswise Expert Predictions
The San Diego Padres face the Seattle Mariners with a pair of starting pitchers on complete opposite ends of a spectrum of production. San Diego’s Yu Darvish (5.36 ERA, 1.10 WHIP) has been a shell of his former self and has been cracked for 4+ earned runs in less than 5.0 innings in a third of his starts this season. He’s especially been rough away from home, posting a 7.66 ERA in starts on the road this season. Meanwhile, Bryan Woo (2.94 ERA, 0.94 WHIP) has recorded four consecutive quality starts, surrendering only 6 earned runs in his last 26.0 innings of work.
Woo is a much more reliable arm in 2025 to lean on. Offensively, Seattle has much stronger splits against right-handed pitchers like Darvish. Seattle ranks 10th in OBP and 6th in wRC+ against RHP this season. I’ll take the Mariners to get a bounce-back win over San Diego.
Padres vs Mariners prediction: Seattle ML (-135) available at time of publishing. Playable at that number or better.
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