San Francisco Giants vs Arizona Diamondbacks Prediction, Odds and Picks for Monday, 06/30/25

The San Francisco Giants head to the Valley of the Sun to tangle with the Arizona Diamondbacks, and they’ll have revenge on their minds. San Francisco lost 2 of 3 games at home against Arizona in the first set at Oracle Park back on May 12-14, with the Diamondbacks snaking a pair of one-run games. The Giants turn to LHP Logan Webb for the opener, and he was stellar in June. The southpaw was 2-0 with a 1.85 ERA, allowing just 7 runs across 34 IP with 6 walks and 36 strikeouts. He did not face the Diamondbacks in the first series of the season. However, last season he was 2-0 with a 0.00 ERA and just 6 hits allowed in 13 scoreless innings, with Arizona hitting only .140 against him.

The Diamondbacks counter with RHP Ryne Nelson, and he was decent in June. He made 4 starts, rebounding from an ugly showing in Cincinnati on June 7. While he had a 4.34 ERA in 4 starts in June, those numbers are skewed because of the game against the Reds. In his past 3 assignments, he allowed just 2 earned runs on a pair of solo home runs across 15.2 IP over his past 3 starts. He worked in relief in his first assignment against the Giants this season, allowing 2 runs in 3 innings on May 14. Nelson should be able to keep the Diamondbacks in what could be a lower-scoring game.

Giants vs Diamondbacks prediction: Diamondbacks +1.5 (-150) available at time of publishing. Playable at that number.

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