San Francisco Giants vs Arizona Diamondbacks Prediction, Odds and Picks for Wednesday, 07/02/25

The San Francisco Giants look to get untracked in the third meeting of this four-game series against the division rival Arizona Diamondbacks. So far, San Francisco was doubled up 4-2 in the series opener Monday, while getting blasted 8-2 in Tuesday’s game, as it had no answers for RHP Zac Gallen. The Giants offense continues to struggle mightily, compiling just nine total runs, or 1.8 runs per game (RPG), across the past five outings. That, combined with the fact the Giants have allowed 17 runs in the past three games, has been a recipe for disaster.

Speaking of disasters, the Diamondbacks were swept by the Miami Marlins over the weekend. However, Arizona has bounced back with a pair of wins, outscoring the Giants 12-4 in the past two games. Despite the sweep against the Fish, Arizona is 8-4 across the past 12 games at home. RHP Merrill Kelly takes the ball for the Snakes, looking to stay hot at home. While he is 3-3, he has a 3.31 ERA and .205 opponent batting average in 51 2/3 IP across nine starts at home. He also has 53 strikeouts in the span. Roll with Arizona until San Francisco shows vast improvement at the plate.

Giants vs Diamondbacks prediction: Diamondbacks -1.5 (+155) available at time of publishing. Playable to +140.

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