San Francisco Giants

San Francisco Giants vs Los Angeles Dodgers Prediction, Odds and Picks for Today, 09/20/25

Dodger StadiumNBCS BA
Giants
76-78
Giants
Today
Dodgers
87-67
Dodgers

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Los Angeles Dodgers
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Giants vs Dodgers Pickswise Expert Predictions

San Francisco Giants
Run Line Pick
LA Dodgers -1.5(-110)

I expect the Los Angeles Dodgers to roll to victory Saturday night as they take on the San Francisco Giants. Los Angeles holds a massive starting pitching edge on paper for this matchup as Tyler Glasnow has far outperformed Kai-Wei Teng this season. Glasnow has dealt with injuries like he usually does, but his 82.1 innings of work so far have resulted in a 3.06 ERA. Luckily for the Dodgers his health is coming at the time they need him most. He enters in good form as well with 3 straight quality starts under his belt.

Teng has just 26.2 innings this season for the Giants, but his 15 walks issued in that span are not conducive to success at this level. His 1.61 walks and hits allowed per inning pitched have resulted in a 6.41 ERA so far, and he is now tasked with the difficult matchup of facing the Los Angeles Dodgers lineup. Look for the Dodgers to provide Glasnow and company with enough runs to win by margin.

Los Angeles Dodgers vs San Francisco Giants prediction: Dodgers -1.5 (-110) available at time of publishing. Playable to -115 odds.

Los Angeles Dodgers
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Javan Shouey

A lifelong sports fan from Northwestern Pennsylvania. Die-hard supporter of the Steelers, Pirates and Cavaliers. Insane passion for writing about sports and helping others improve. Incredibly thankful for the platform Pickswise is giving me. For Javan Shouey media enquiries, please email contact@pickswise.com.
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