St. Louis Cardinals vs Chicago Cubs Prediction, Odds and Picks for Today, 09/28/25

The Chicago Cubs are looking to close out their successful 2025 regular season with their 92nd win of the season as they take on the St. Louis Cardinals. Javier Assad is their scheduled starter as the right-hander makes his 8th appearance of the season. His first 7 outings have totaled 31.2 innings with a 4.26 ERA including 6.1 innings of 2-run ball in his last 2 outings. It remains to be seen how he will be utilized in the postseason, but it is likely that he becomes a multi-inning reliever for them. We could see a short leash for him in this spot.

The Cardinals are under .500 again and ending this season in 4th place in the National League Central regardless of today’s outcome. St. Louis is starting Kyle Leahy in this game as they utilize a bullpen game to close their season. The Cardinals’ right-hander has 85 innings under his belt this season with a 3.18 ERA but likely doesn’t work more than an inning or 2. I favor the Cubs in this game given their superior roster and reasonable price.

Chicago Cubs vs St. Louis Cardinals prediction: Cubs ML (-160) available at time of publishing. Playable at that price.