Tampa Bay Rays vs Chicago White Sox Prediction, Odds and Picks for Today, 04/15/26

The Tampa Bay Rays are set to take on the Chicago White Sox on Wednesday night at Rate Field. Tampa Bay took the first game of this series by a score of 8-5 on Tuesday night. The Rays will send right-hander Jesse Scholtens to the mound, and he will be making just his fourth big league appearance since 2023. His first outing of this season resulted in 4.2 scoreless innings against the Cubs, but given his inexperience, it would be a bit surprising to see a repeat performance of that caliber. Plus, that outing came at home, while this will be his first road outing of the season. The White Sox don’t have the best lineup out there, but they have scored 11 total runs over their last 2 games.

Chicago will send Sean Burke to the mound, and he has a tough matchup facing a Tampa Bay lineup that is rolling. The Rays have scored at least 5 runs in every game during their 4-game win streak, and they ranks 5th in the league with a .266 batting average in the early going this season. Both bullpens have been shaky, owning ERA’s well above 5.00. So even if one or both starters perform well, each offense still has some hope going up against either bullpen. Look to the over in this one.

Rays vs White Sox prediction: Over 8 (-105) available at time of publishing. Playable at that number.