Tampa Bay Rays vs Toronto Blue Jays Prediction, Odds and Picks for Today, 09/27/25

The Toronto Blue Jays have squandered their large lead in the AL East and are now tied with the New York Yankees atop the division with just 2 games remaining. I expect the Yankees to win Saturday, making it crucial that the Blue Jays keep pace. Trey Yesavage is set to make his 3rd career MLB appearance for Toronto in this game in an intense setting. It will be his first time pitching in front of his home crowd after 2 road starts, and the hope is that his command will improve from his last outing where he issued 3 free passes. Yesavage tore through the minor leagues this season, posting a 3.12 ERA, 2.52 FIP, and a 14.69 K/9 in 98 combined innings across all levels. I expect 5 strong innings from him in this spot.

Joe Boyle, like Yesavage, has both high strikeout upside and control questions, but Boyle’s on-field performance has not been as good as the Rays hoped for in 2025. Through 47 innings his 25 walks issued and his 4.40 ERA are less than ideal, and he is also tasked with facing the tougher lineup in today’s game. Toronto is an improved offensive unit this season and they should provide Yesavage and company with enough run support to win this game.

Toronto Blue Jays vs New York Yankees prediction: Blue Jays ML (-160) available at time of publishing. Playable at that price.