The Athletics vs Los Angeles Angels Prediction, Odds and Picks for Today, 09/06/25

While not my favorite game from a betting perspective on Saturday’s loaded MLB slate, I do lean towards the over on the posted game total in the matchup between the Athletics and the Angels. J.T. Ginn is set to start for the Athletics, marking his 20th appearance and 13th start of the season. He enters play with a 5.17 ERA in 71.1 innings of work, and despite above-average strikeout production there is not much else of intrigue in his portfolio. I expect the Angels to produce offensively in this matchup.

Yusei Kikuchi has a respectable 3.83 ERA entering this game, but that comes after 11 earned runs and 3 home runs allowed within his last 2 starts alone. Those outings were against AL West foes in the Rangers and Astros, and now Kikuchi is tasked with another AL West opponent in the Athletics. While certainly an inconsistent offensive unit, the Athletics have enough power to make Kikuchi pay for weak command of the zone, and I lean towards the over in this game.

The Athletics vs Los Angeles Angels prediction: Over 9 (-115) available at time of publishing. Playable at that price.

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