The Athletics vs St. Louis Cardinals Prediction, Odds and Picks for Today, 09/01/25

The Athletics travel to meet the St. Louis Cardinals at Busch Stadium on Monday afternoon to kick off a three-game interleague series. The A’s had been playing good ball, but they suffered a three-game sweep at the hands of the Texas Rangers over the weekend, while getting outscored 23-11. The Over has cashed in each of the past two games, but the Under is 7-4 in the past 11 games on the road for the Athletics. The A’s turn to RHP Luis Morales for the start, and he is 2-0 with a 1.19 ERA across 22 2/3 IP with a 0.97 WHIP in four starts and one relief appearance.

The A’s try to get back on track against former A’s pitcher Sonny Gray, but they’re just 15-24 this season in interleague play, and 34-35 on the road. Gray is 12-7 with a 4.19 ERA and 1.18 WHIP in 27 starts this season, but he has done his best work at home. He is 8-4 with a 3.57 ERA across 95 2/3 IP with a 1.25 WHIP across 17 starts. The Cards are 37-32 at home, but just 20-22 against the American League this season. The Cardinals have gotten pretty decent pitching lately, allowing two or fewer runs in three of the past five games, with the Under going 3-2 in those outings. It might have trouble scoring against Morales, and the A’s have had trouble scoring against everybody. Go low on the total in the First 5 Innings, and the under is a good play for the whole game as well.

Athletics vs Cardinals prediction: F5 Under 4.5 (-125) available at time of publishing. Playable to -140.

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