Detroit Pistons vs Milwaukee Bucks Prediction, Odds and Picks for Today, 11/22/25

What a difference a year can make. Last season the Pistons won their 13th game of the season on December 30; this season it took them 40 fewer days to achieve that feat. The turnaround is truly remarkable. I would imagine not a lot of people had Detroit leading the East after 15 games played, with a 3-game advantage over the Cavaliers. Saturday will see the Pistons take on a wounded Bucks team, with a chance to reverse a trend that’s been going on for the past 3 seasons. Detroit has lost 13 games in a row to Milwaukee dating back to the 2021-22 season; the way things are going right now, this is an ideal opportunity to end that streak.

No Giannis Antetokounmpo for Milwaukee spells trouble. The Bucks automatically go from being the #1 offense in the NBA all the way to the bottom. Even though they scored 114 on the Sixers in their last game and took Philly to overtime, their weaknesses may be exposed when facing a quality team like the Pistons. Only the OKC Thunder have a better defensive rating this season than the Pistons do. Ball movement is something the Bucks will struggle with, as Detroit allows the fewest assists per game this season. They also force the second-most turnovers, so things just aren’t looking bright for the Bucks at the moment.

Milwaukee is 1-6 ATS in 7 games and it has won just once in 5 overall, as well. Against East opponents the Bucks have covered the spread only twice in 7 games. They will face stiff competition in their next 4 games and if things don’t improve rapidly we could be looking at a 8-12 record before Giannis returns. The Pistons have won 11 in a row and they have covered 9 times during this stretch.

Pistons vs Bucks prediction: Detroit -8.5 (-110) available at time of publishing. Playable at that number.

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