San Antonio Spurs vs Cleveland Cavaliers Prediction, Odds and Picks for Today, 12/05/25

The San Antonio Spurs may be missing Victor Wembanyama, but they are still 7-2 since their big man went down as they prepare to visit the Cleveland Cavaliers on Friday night. A sample size of nine games is large enough to confirm that San Antonio is just fine — at least in the short term — without Wembanyama, so my Spurs vs Cavaliers pick is for the visitors to cover a +5.5 spread. How are the Spurs getting by despite being undermanned? Well, a whopping 7 players on the roster — not even including Wembanyama — are scoring in double-figures. De’Aaron Fox leads the way at 25.0 ppg, while Stephon Castle comes in at 17.5 ppg and Devin Vassell contributes 15.7 ppg. Rookie Dylan Harper, the #2 overall pick, is doing a little bit of everything with 13.6 ppg, 3.5 apg, 3.0 rpg and 1.1 spg. San Antonio gets after it on the defensive end of the floor, too, boasting 6 guys who average more than a steal per game.

Cleveland’s 2025-26 campaign has been unspectacular relative to the standards it set for itself last season. The Cavs are 13-10 and have dropped 4 of their last 5 contests. Much unlike last year, they are not even dominant in their own building — sporting an 8-5 such record in advance of Friday’s tilt. Head coach Kenny Atkinson’s crew had lost 2 in a row at home, including to Portland 122-110 on Wednesday. Center Jarrett Allen (finger) and guard Darius Garland (toe) are both out. In their current state, the Cavs probably can’t cover a relatively sizable spread against a very good opponent.

Spurs vs Cavaliers prediction: San Antonio +5.5 (-105) available at time of publishing. Playable to +5.

You can bet on our Spurs vs Cavaliers pick at DraftKings Sportsbook, which has thousands of betting options available and a great new customer offer where you can get $200 in bonus bets instantly AND $200 off NFL Sunday Ticket! Click here 👈🏼 to sign up for a DraftKings account now.