Four-pick cross-sport parlay for Friday (+1059 odds): NFL preseason, MLS, EPL, and MLB picks

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Matthew Lowrimore


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Matthew has been with Pickswise for a while now, covering a wide variety of sports. His main passions are college football and UFC, and those are the sports he has covered the most. Matthew uses a variety of methods to handicap games, including stats, trends, injuries, and situational factors. His goal is to consistently give out winners and will put in the research to try and achieve this. For Matt Lowrimore media enquiries, please email
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We have put together a four-pick cross-sport parlay that will take you right through Friday night, including action from the NFL preseason, MLB, EPL, and MLB.

One pick is taken from each sport and a winning ticket gives us a nice payout with odds at +1059 with BetMGM: that’s more than 10/1! Let’s break down each of these 4 plays. Remember to gamble responsibly.

EPL Pick: Arsenal ML (+100) vs Brentford, 3pm ET

Brentford plays its first-ever Premier League game when they host Arsenal in the season opener on Friday night, but it may not be a winning start for Thomas Frank’s side. Arsenal’s young talent, coupled with the signing of Ben White has renewed optimism in north London and Mikel Arteta will be looking to the likes of Buyako Saka and Emile Smith Rowe to push them into the top four.

The Gunners can also call on Alex Lacazette, Pierre-Emerick Aubameyang, and Nicolas Pepe in attack, and Pepe, in particular, could be set for a big season. That attacking talent could prove too much for newly-promoted Brentford and Arsenal can get their season off to a winning start.

Be sure to check out our full game preview for Arsenal vs Brentford.

NFL Preseason Pick: Buffalo Bills +1.5 (-115) vs Detroit Lions, 7pm ET

The Bills have a huge group of talented running backs all out to secure a spot. Devin Singletary and Zack Moss operated well last year as a tandem, but Antonio Williams showed his value with two touchdowns in the Week 17 demolition of the Dolphins. Meanwhile, Matt Breida and Taiwan Jones are both respected running backs and should have success against this sub-par Lions defense. Detroit’s good players are few and far between, and new head coach Dan Campbell could be in for a nasty surprise in his first game in charge. It’s also worth noting that the Bills went 4-0 in their last preseason, while the Lions went 0-4. Expect both those streaks to continue.

Be sure to check out our full game preview for Buffalo Bills vs Detroit Lions.

MLB pick: Oakland Athletics vs Texas Rangers – Under 8 Runs (-110), 8:05pm ET

Pitching at home in 2021, Dane Dunning is one of baseball’s best pitchers–posting a 26.1 strikeout-percentage against a 7.0 percent walk-rate. He limits traffic on the bases, evident by a 1.19 WHIP. Cole Irvin has been much better on the road compared to pitching at home. He should be able to deliver a strong outing this evening against a Texas lineup that struggles to hit lefties, and ranks dead-last in the league in most major offensive categories since the all-star break. In night games in 2021, Globe Life Field ranks 17th out 30 ballparks in offensive production. Expect a low-scoring affair in this one.

Be sure to check out our full game preview for this matchup. You can also read the rest of our MLB picks and predictions, as well as our prop betsparlays, and MLB Best Bets

MLS Pick: Vancouver Whitecaps (-160) vs San Jose Earthquakes ML, 10:30pm ET

San Jose are coming off a 2-1 victory against LAFC, and while the team didn’t play perfect soccer throughout the match, they hung tough against a struggling yet dangerous team to keep all 3 points. They have now gone 7 straight matches without losing, pulling off another strong win at Seattle in addition to their 5 draws. They don’t look like they’ll be letting up any time soon as the season heads into the second half, so take San Jose on the money line.

Be sure to check out our full game preview for Vancouver Whitecaps vs San Jose Earthquakes.

Pickswise is the home of free MLB picks and predictions. Make sure to check out our MLB parlays and MLB prop bets tabs for more expert picks.

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