Man vs Machine: Pickswise expert vs the computer model NFL Week 16 best bets

Jacksonville Jaguars quarterback Trevor Lawrence (16) rolls out to throw a pass in the first quarter of a preseason game against the Dallas Cowboys at AT&T Stadium.
Photo of Andrew Ortenberg

Andrew Ortenberg

NFL

Show Bio

I'm an NFL handicapper here at Pickswise who was raised in a household full of sports fanatics. Since I unfortunately never had LeBron James' jumping ability I wasn't able to make it to the NBA, and chose writing about sports as the next best thing. An avid sports bettor myself, I'm excited to get to write about the industry as it gets set to take off across the country. Buckle up.

Man vs Machine

Welcome to the 2021 edition of Man vs Machine. This NFL season, I’ll be making my five best NFL bets each week. Our Pickswise supercomputer will make its best five bets, and then we’ll compare. May the best man (or machine) win.

Our computer model gives probabilities and projections for the main NFL betting markets (spread, total & money line), best bets for spread, total, money line, and same game parlays. It also features prop bet probabilities for first and anytime touchdown scorer, plus individual player projections for passing, rushing, receiving yards, and touchdowns for betting and fantasy use.

For more information on how the supercomputer works and how it generates picks, scroll down to the bottom of this page. Now let’s look at the picks.

My 5 best bets

Jaguars +1.5 over Jets

Call me crazy, but I like the Jaguars a lot this week. Trevor Lawrence hasn’t had an ideal rookie season by any stretch of the imagination, but he hasn’t looked as lost as Zach Wilson. With the Jets dealing with a Covid-19 outbreak, as well, I think Jacksonville will pick up its first win of the post-Urban Meyer era.

Chargers -10.5 over Texans

I don’t often take double-digit favorites, but this one shouldn’t be close. The only thing making this Texans offense watchable recently has been Brandin Cooks, and now he’s out with Covid-19. About half of Houston’s defense is also out, so Justin Herbert should shred the Texans.

Vikings +3.5 over Rams

This number is just too high for the Rams to lay on the road. Everyone has jumped back on the Los Angeles bandwagon after just having buried this team a couple of weeks before. The Rams are now being overvalued.

Broncos pick ’em over Raiders

I don’t think Drew Lock is much of a downgrade from Teddy Bridgewater. And the Broncos’ ground game should have some success against a weak Raiders run defense. Denver’s defense is trending up, while Las Vegas’ offense is trending way down.

Washington +10 over Cowboys

Give me Washington on Sunday Night Football. Dallas’ offense isn’t playing well, so there’s no way I could lay double-digits with them here. They only won big last week because Mike Glennon pulled a Mike Glennon for the Giants, as Dak Prescott had yet another lackluster day.

Computer picks

Jaguars +1.5 over Jets, Bills +1 over Patriots, Vikings +3.5 over Rams, Broncos pick ’em over Raiders, Steelers +10 over Chiefs

The computer and I are thinking alike this week. We’re on three of the same sides: Jacksonville, Minnesota, and Denver. Interestingly, our system is going with the Bills over the Pats in the slate’s most highly anticipated matchup. It’s also willing to roll with Ben Roethlisberger at Arrowhead. Both myself and the computer went 3-2 last week; hopefully we can each have another winning record in Week 16.

2021 season results

Pickswise Expert (36-39)
Pickswise Computer (44-30-1)

Don’t forget to check out our free picks on the side and total for every NFL game. You can also view all of our computer picks.

How are the pre-game win probabilities calculated?
The Pickswise supercomputer creates pre-game probabilities using machine learning techniques as inputs to a Monte Carlo approach. This means we simulate a sporting event 10,000 times, catering for the deep range of outcomes and probabilities within a given event. We first predict the performance of each individual player based on hundreds of algorithmic variabilities, which we use to run our event simulations.

Why do the win probabilities and predictions change over time?
The probabilities are dynamic in nature and get updated as new information becomes available. This includes but is not limited to team news, weather conditions, and moves in the betting market.

What does a ‘value bet’ mean?
A value bet is where we have identified that the probability of the event occurring is more likely than the listed sportsbook odds. Taking these bets gives you an increased chance of being a successful gambler.

How is the change in win probability calculated during a live game?
Live win probability is a statistical metric that projects the team’s likelihood of winning at any given point by simulating the remainder of the game. Based on the performance of historical teams in the same situation and the current state of the game, the model updates in real-time following every major event during the game.

Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.

Virginia Bonuses

See All
BetMGM
EXCLUSIVE OFFER: Bet on CBB Tournament and get $1,000 Paid Back in Bonus Bets if you Don't Win + $25 Bonus Bet

Register for a new BetMGM account & deposit

Place your first bet and get refunded up to $1,000 in bonus bets if you don't win

Plus receive a $25 Bonus Bet after placing your qualifying wager

Gambling problem? Call 1-800-GAMBLER CO, OH, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY 21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). Visit BetMGM.com for Terms & Conditions. US promotional offers not available in DC, Nevada, New York or Ontario
FanDuel Sportsbook
Get a $1,000 No Sweat Bet on any CBB Tournament Game!

Sign up for a new FanDuel Sportsbook account

Make a first-time deposit of $10+, and then place your first real-money wager on FanDuel Sportsbook

New customers get their first bet paid back in bonus bets up to $1,000 if you lose!

Must be 21+. First online real money wager only. $10 first deposit required. Bonus issued as non-withdrawable free bets that expire 14 days after receipt. See full terms at fanduel.com/sportsbook.
DraftKings
Bet $5+ any College Basketball Pre-Game ML And Get $150 in Bonus Bets if your Team Wins

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Make your first deposit and bet $5+ on any pre-game ML

Get $150 in bonus bets if your team wins

Gambling Problem? Call 877-8-HOPENY/text HOPENY (467369) (NY), If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (CO/IL/IN/LA/MD/MI/NJ/PA/TN/WV/WY), 1-800-NEXT STEP (AZ), 1-800-522-4700 (KS), 888-789-7777/visit ccpg.org (CT), 1-800-BETS OFF (IA), or 1-888-532-3500 (VA). 21+ (18+ WY). Physically present in AZ/CO/CT/IL/IN/IA/KS/LA(select parishes)/MD/MI/NJ/NY/PA/TN/VA/WV/WY only. Void in OH/ONT. Eligibility restrictions apply. Valid 1 per new customer. Min. $5 deposit. Min. $5 bet. $150 issued as bonus bets that expire 7 days (168 hours) after being awarded. See terms at sportsbook.draftkings.com..
Unibet
Virginia Bettors- Get a $100 Free Bet for the CBB Tournament

Register for a new Unibet account & make a deposit

Place your first bet up to $100 free!

Get refunded up if you lose up to $100

New players only. Terms & conditions apply. 21+. VA only.
bet365
Bet $1 on the CBB Tournament and Get $365 in Bonus Bets at bet365!

Register for a new bet365 account

Place qualifying bets of $1 or more

Get $365 in bonus bets - no matter if your bet wins or loses

New Customer Offer. Deposit required. Bonus Bets added to Bonus Bet Credits balance. Bonus Bet risk excluded from returns. T&Cs, time limits, and exclusions apply. Must be physically located in VA.
WynnBet
Bet $100 on the CBB Tournament & Get $100 Bet Credit

Register for a WynnBET account today.

Deposit & Wager $100 on any sports market (odds -120 or greater).

Get a $100 Bet Credit.

Must be 21+. Gambling Problem? Call 1-800-GAMBLER
BetRivers
Get a $500 Free Bet for the CBB Tournament

Sign up for a new BetRivers account using promo code PICKSWISE

Make your first deposit & get up to $500 in free bets

To get $500 in free bets, wager $500

Must be 21+. Gambling Problem? Call 1-800-BETS OFF
Caesars Sportsbook
Your First Cash Bet on the CBB Tournament Is On Caesars Up To $1,250

Sign up for a new Caesars Sportsbook account and Place your 1st wager of $10 or more

If you lose, you get 100% of your stake back as a Bet Credit - up to $1,250.

AND win or lose, you’ll also get 1,000 Reward Credits® and 1,000 Tier Credits.

21+. Terms and conditions apply.
DraftKings
Get a $1,000 Deposit Bonus When you bet on the CBB Tournament

Create a new DraftKings Sportsbook account and make your first deposit (min $5)

DraftKings will match 20% of your deposit up to $1,000 total

To get a $100 bonus, deposit $500

21+. Terms & conditions apply.
BetMGM
Get $1,000 Paid Back in Bonus Bets if you Don't Win your CBB Tournament Bet

Register for a new BetMGM account & deposit

Place your first bet up to $1,000!

Get refunded up to $1,000 in bonus bets if you don't win

Gambling problem? Call 1-800-GAMBLER CO, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY 21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). Visit BetMGM.com for Terms & Conditions. US promotional offers not available in DC, Nevada, New York or Ontario
DraftKings
Get a +1000 Odds Boost for Any Golfer to Win The Masters

Create a New DraftKings Account

Make Your First Deposit Of $5+ Into Your Sportsbook Account

Following Sign Up, You’ll Be Issued With One (1) Single-Use +1000 Odds Surge Token For Any Golfer To Win Any Tournament

Gambling Problem? Call 877-8-HOPENY/text HOPENY (467369) (NY), If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (CO/IL/IN/LA/MD/MI/NJ/PA/TN/WV/WY), 1-800-NEXT STEP (AZ), 1-800-522-4700 (KS), 888-789-7777/visit ccpg.org (CT), 1-800-BETS OFF (IA), or 1-888-532-3500 (VA). 21+ (18+ WY). Physically present in AZ/CO/CT/IL/IN/IA/KS/LA(select parishes)/MD/MI/NJ/NY/PA/TN/VA/WV/WY only. Void in OH/ONT. Eligibility restrictions apply. Valid 1 per new customer
Underdog Fantasy
First deposit is 100% matched up to $100 with Underdog Fantasy

Sign up for a new account with Underdog Fantasy

Make your first deposit

Every dollar (up to $100) will be matched! Deposit $25, get $50; deposit $100, get $200, etc

Must be 21+ to play. Terms & conditions apply
Owners Box
First Time Deposit Bonus Up To $500

Sign up for a new DFS account with OwnersBox

User's first deposit will be matched up to $500 in site-credit

Join one of their Daily NFL, NBA, MLB, or NHL contests

You must be at least eighteen (18) years of age to receive deposit bonuses, participate in Contests, or win prizes offered through OwnersBox Contests. In jurisdictions, territories, and locations where the minimum age for permissible use of Contests is greater than eighteen (18) years old, you must meet the age requirement in your local jurisdiction or territory.
TVG
Get Your First Single-Horse Win Wager Back Up to $200 if you don't win

Register for a new TVG account and make a deposit

Place your first single horse win-type bet up to $200

If your horse doesn't win you'll get a refund up to $300

21+. T&C's apply. Please gamble responsibly.
TwinSpires
Get a $200 Sign-Up Bonus with Twinspires Racebook!

Open your TwinSpires.com account using offer code BET200

$200 bonus cash will be credited in increments of $100 for every $400 wagered

To earn the full $200 bonus players must wager $800 within 30 days

21+. Terms and conditions apply.