NFL Daily Fantasy Football Picks for Buffalo Bills vs Los Angeles Rams: Josh Allen to start the season strong

Photo of Howard Bender

Howard Bender

NFL

Show Bio

NFL betting analyst for Pickswise. I have been working in the fantasy sports industry for more than 20 years. I am the head of fantasy sports content for Fantasy Alarm and DFS Alarm as well as a bi-weekly columnist for the New York Post.

With sports betting slowly becoming legalized in more and more states, the excitement over the start of the 2022 NFL season is unlike that of any other sport. Everyone loves betting on football. You have already laid out your team futures action and are now probably scouring through the various game lines and player props, looking for the best value plays out there. If you are looking for another way to have some skin in the game, particularly for tonight’s Thursday Night Football kickoff between the Buffalo Bills and defending Super Bowl champion Los Angeles Rams, it’s time to dip your toe into the NFL DFS pool and play tonight’s Showdown slate.

Thursday Night Football in Week 1 is loaded with top players, so all you need to do is build a five or six-man lineup — depending on what DFS site you choose — and watch the points roll in. Here are some top suggestions you may want to consider.

MVP/Captain

Josh Allen, QB LAR

Price permitting, everyone loves jamming a quarterback into their captain seat — especially if he has that 300-yard, multi-touchdown upside like Allen does. There was all sorts of talk from new offensive coordinator Ken Dorsey about balancing the offense more with a stringer ground game, but given the Rams’ defensive line and the addition of inside linebacker Bobby Wagner, rushing yards may be tough to come by. Allen should set up nicely with his receivers to attack the Rams downfield and let’s not forget his penchant for picking up rushing touchdowns inside the green zone.

Cooper Kupp, WR LAR

While you never like to upset the apple cart, will the departure of Kevin O’Connell have an adverse effect on the Rams passing game? Probably not. New OC Liam Cohen was the Rams tight ends coach last season so he is very familiar with the system which is being left in place under Sean McVay. Kupp lines up all over the field and is incredibly elusive in coverage. Matthew Stafford has used him as a bit of a security blanket and that is unlikely to change this season. The fact that the Bills are missing Tra’Davious White in the secondary should help boost Kupp’s overall value.

Matthew Stafford, QB LAR

Just like Allen, Stafford is expected to take control of this offense and while there have been elbow issues throughout the summer, he is good to go and ready for tonight’s game. The elbow may come back to be a thing a little later on in the season, but for tonight we aren’t concerned. He has Kupp to rely on, as always, but he also has an incredible asset in Allen Robinson. We have heard Cohen also talk about balancing the offense and running more, but if you’re investing heavily in someone from this offense, Stafford is a great pick.

Stefon Diggs, WR BUF

This actually might be a little contrarian as most people just assume Rams cornerback Jalen Ramsey will shadow Diggs throughout this game. But if you have watched over the past year or two, Ramsey doesn’t shadow receivers anymore. Diggs will be moved all around the field so that he’s not opposite Ramsey all night and he should be fed a significant share of the targets. Using him in the captain seat should save you a few bucks, too.

Stefon Diggs of the Buffalo Bills

Other Plays

Allen Robinson, WR, LAR

After a miserable season in Chicago last year, Robinson is ready to break out today and show his new team just how smart they were to invest in him. Obviously, he plays second fiddle to Kupp, but we’ve watched the likes of Robert Woods and Odell Beckham thrive in this offense while Kupp draws the heavy coverage. Robinson is old enough to know “you never get a second chance to make a first impression,” so look for him to try and stand out.

Gabriel Davis, WR, BUF

Now that the Bills have full committed to Davis as their Z-receiver, the masses are expecting a big breakout season for the third-year wideout. He’s got the speed to stretch the field and we watched last year as he caught 13 passes for over 20 yards, so expect Allen to take a few deep shots downfield to him. Just keep in mind that he is likely to be very chalky this evening so if you are looking to go against the grain, he might not be the right choice for you.

Cam Akers, RB, LAR

Things appeared to be slow-going for Akers this summer as he continues to work himself back into game-shape following a ruptured Achilles’ tendon. He did not look good in his late-season comeback last year and the team handled him with kid gloves throughout camp. However, he returned to full practices all of last week and we know Cohen wants to do some more ground work this season. He can also be expected to handle any goal-line work the Rams find themselves in tonight.

Darrell Henderson, RB, LAR

He is a quality pass-catching, change-of-pace back the Rams will weave into the game plan tonight and he is likely to handle the majority of the third-down work. He was dealing with an undisclosed injury late in camp, but like Akers, he was back at full-practice early last week. It’s tough to predict just how committed to the run Cohen and McVay will be, but also keep in mind that — if this game becomes a shootout — Henderson will likely be on the field more for receiving work.

Isaiah McKenzie, WR, BUF

While most people stare at Davis, McKenzie could be the ultimate sleeper in this Bills offense. A quick glance at the target distribution for the Bills last year shows you that it was slot receiver Cole Beasley who saw the second-most targets on this team. Davis split his share with Emmanuel Sanders, but even combined they fell short of Beasley’s totals. McKenzie will be the third receiver on the field and while he can play all over, he is expected to work primarily out of the slot. And that price tag? Super tasty.

Devin Singletary, RB, BUF

Will the Bills commit to the run? That’s the big question on everyone’s mind right now. Singletary was absolutely dominant for fantasy owners and DFS players down the stretch last season as the Bills gave him the ball more in the last six games (including the playoffs) than they had all season and the results were spectacular with one 100-yard effort, three more games with over 80 yards and eight touchdowns. It’s still likely a three-way split in the Buffalo backfield, but Singletary should see the bulk of the work.

Side Note: You can also use kickers for your lineups, so don’t ignore Matt Gay or Tyler Bass. With a game total sitting at 52, you know there will be plenty of points scored.

Dart Throws

Ben Skowronek, WR, LAR

If you’re just trying to get a little weird and contrarian, then Skowronek just might be your guy. Van Jefferson is out with a knee injury, which pushes Skowronek up the depth chart and onto the field for three-receiver sets. You won’t see a strong target share, but he has the speed to stretch the field and if Stafford is looking to take a quick, deep shot down the field, he could beat be the guy to beat the coverage on a post pattern.

Khalil Shakir, WR, BUF

This is the ultimate dart throw, as Shakir seems buried on the depth chart as the fifth wide receiver. However, he was very impressive this summer and there is no reason to think that the Bills won’t give him a look if they want to spread the field and go with a four or even five-receiver set. He has a little more excitement surrounding him than Jamison Crowder and the price tag is super low.

For additional NFL DFS Week 1 coverage, check out our full coverage on Fantasy Alarm.

Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.

Virginia Bonuses

See All
Unibet

$100

Get a $100 Risk-Free Bet!

Register for a new Unibet account & make a deposit

Place your first bet up to $100 risk-free!

Get refunded up if you lose up to $100

New players only. Terms & conditions apply. 21+. VA only.

BetRivers

$500

Get a $500 Risk-Free Bet on Colts vs. Broncos!

Sign up for a new BetRivers account using promo code PICKSWISE

Make your first deposit & get up to $500 in free bets

To get $500 in free bets, wager $500

Must be 21+. Play in IA Only. Gambling Problem? Call 1-800-BETS OFF

FanDuel Sportsbook

$1,000

Get a $1,000 No Sweat First Bet on Colts vs. Broncos

Sign up for a new FanDuel Sportsbook account and make your first deposit of $10+

Place your first bet up to $1,000!

Get refunded up if you lose up to $1,000

Must be 21+. First online real money wager only. $10 first deposit required. Bonus issued as non-withdrawable free bets that expire 14 days after receipt. See full terms at fanduel.com/sportsbook.

DraftKings

$200

Bet $5+ on Colts or Broncos ML, Get $200 If Your Team Wins

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Bet $5+ on the pre-game ML in any sport

Win $200 if your team wins

Offer valid for new players only. Must be 21 years or older to play. Reward paid in site credit. Full terms available at DraftKings Sportsbook.

PointsBet

$800

Get 4x $200 In Free Bets on Colts vs. Broncos

Sign up for a new PointsBet account

Bet up to $200 and If you lose, you get a refund

You will receive Free Bet(s) in the amount of the losing wager(s), up to $200 each for four days.

Must be 21+. Full terms are available at PointsBet.

Caesars Sportsbook

$1,250

Get a $1,250 risk-free bet on Colts vs. Broncos

Sign up for a new Caesars Sportsbook account

Place your first bet of $10 or more

If your first bet loses, you’ll receive a refund up to $1,250 from Caesars in free bets

21+. Terms and conditions apply.

BetMGM

$1,000

Get a $1,000 Risk Free Bet on Colts vs. Broncos

Register for a new BetMGM & deposit

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

21+. Terms & conditions apply.

DraftKings

$100

Bet $5+ on MLB and get $100 in Free Bets Instantly!

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Bet $5+ on any MLB team to win their next game

Win $100 no matter what!

Offer valid for new players only. Must be 21 years or older to play. Reward paid in site credit. Full terms available at DraftKings Sportsbook.

PointsBet

$500

Get 5x $100 in Free Bets on Colts vs. Broncos

Sign up for a new PointsBet account

Make a bet of up to $100 and receive a refund if you lose

Get this offer once a day for the first 5 days you sign up

Must be 21+. Full terms are available at PointsBet.

DraftKings

$1,000

Get a $1,000 Deposit Bonus!

Register for a new DraftKings Sportsbook account & deposit

DraftKings will match 20% of your deposit up to $1,000 total

To get a $100 bonus, deposit $500

21+. Terms & conditions apply.

PointsBet

$2,000

Get $2,000 in Free Bets on Colts vs. Broncos

Register for a new PointsBet account & deposit

Receive a free bet refund up to $500 if your first fixed odds bet loses

& a free bet refund up to $1,500 if your first two PointsBetting Wager loses

Must be 21+. Full terms are available at PointsBet.

Monkey Knife Fight

$100

Claim Instant Deposit Match up to $100 + Free $5 game

Register for a Monkey Knife Fight account & deposit using promo code PICKSWISE100

Monkey Knife Fight will match your first deposit up to $100

Deposit $100 and you'll get $100 bonus + a free $5 game

18+. Terms and conditions apply. You must live in one of the states where real money DFS is legal.

TVG

$200

Get Your First Single-Horse Win Wager Back Up to $200 if you don't win

Register for a new TVG account and make a deposit

Place your first single horse win-type bet up to $200

If your horse doesn't win you'll get a refund up to $300

21+. T&C's apply. Please gamble responsibly.

TwinSpires

$200

Get a $200 Sign-Up Bonus with Twinspires Racebook!

Open your TwinSpires.com account using offer code BET200

$200 bonus cash will be credited in increments of $100 for every $400 wagered

To earn the full $200 bonus players must wager $800 within 30 days

21+. Terms and conditions apply.

Underdog Fantasy

$100

First deposit is 100% matched up to $100 with Underdog Fantasy

Sign up for a new account with Underdog Fantasy

Make your first deposit

Every dollar (up to $100) will be matched! Deposit $25, get $50; deposit $100, get $200, etc

Must be 21+ to play. Terms & conditions apply