NFL Week 12 Opening Odds, Betting Lines, and spreads: Four days of football on Thanksgiving week!

We have arrived at Week 12 of the 2023 NFL season; it should be a fun one, too. After all, it’s Thanksgiving week! That means we have 3 games on Thursday in addition to a Black Friday special between the Dolphins and Jets. We also have a pair of interesting showdowns on Sunday as the Bills battle the Eagles and the Jaguars face the Texans in a huge AFC South matchup.

Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week. Meanwhile, we currently boast a 35-24 NFL best bets record — so don’t forget to give that page a look. For now, let’s break down the NFL Week 12 opening lines and give our best early bet to make. 

NFL Week 12 opening lines and odds

Odds available at DraftKings Sportsbook at time of publishing. 

Green Bay Packers +7.5 (-110) vs Detroit Lions -7.5 (-110) — Thursday
Washington Commanders +11 (-110) vs Dallas Cowboys -11 (-110) — Thursday
San Francisco 49ers -7 (-110) vs Seattle Seahawks +7 (-110) — Thursday
Miami Dolphins -7.5 (-110) vs New York Jets +7.5 (-110) — Friday
New Orleans Saints PK (-110) vs Atlanta Falcons PK (-110)
Jacksonville Jaguars -1 (-110) vs Houston Texans +1 (-110)
Tampa Bay Buccaneers +1 (-110) vs Indianapolis Colts -1 (-110)
New England Patriots -5.5 (-110) vs New York Giants +5.5 (-110)
Carolina Panthers +4 (-110) vs Tennessee Titans -4 (-110)
Los Angeles Rams -1 (-110) vs Arizona Cardinals +1 (-110)
Cleveland Browns +1 (-110) vs Denver Broncos -1 (-110)
Buffalo Bills +3.5 (-110) vs Philadelphia Eagles -3.5 (-110)
Kansas City Chiefs -9.5 (-110) vs Las Vegas Raiders +9.5 (-110)
Baltimore Ravens -4 (-110) vs Los Angeles Chargers +4 (-110) — Sunday Night Football
Chicago Bears +3.5 (-110) vs Minnesota Vikings -3.5 (-110) — Monday Night Football 

Best early bet for NFL Week 12: Baltimore Ravens -4 over Los Angeles Chargers (-110)

It’s time – or perhaps even past time – to recognize the Ravens as legitimate Super Bowl contenders. They may not have the most electric roster outside of quarterback Lamar Jackson, but with Jackson running the show on offense and a stout defense from top to bottom this team is as well-rounded as it gets. Baltimore is now 8-3 following Thursday’s 34-20 victory over Cincinnati. 

Up next for head coach John Harbaugh’s squad are the Chargers, who are 4-6 and have lost 4 of their last 6. They appeared to lose Joey Bosa to a significant injury in Week 11, too. The Ravens also have the benefit of a long week since they just played on Thursday Night Football. I think the visitors can win this game by at least a touchdown. 

We’ll have NFL Week 12 picks for every game this week