NFL Week 8 three-team mega parlay (+1282 odds): Jaguars can make it two in a row

Jacksonville Jaguars quarterback Trevor Lawrence (16) scrambles with the ball against the Arizona Cardinals during the first half at TIAA Bank Field.
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I'm an NFL handicapper here at Pickswise who was raised in a household full of sports fanatics. Since I unfortunately never had LeBron James' jumping ability I wasn't able to make it to the NBA, and chose writing about sports as the next best thing. An avid sports bettor myself, I'm excited to get to write about the industry as it gets set to take off across the country. Buckle up. For Andrew Ortenberg media enquiries, please email
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The 2021 NFL season has been great so far, and we have another exciting slate on Sunday for Week 8. Why not celebrate the fun by going for a big payday? That’s right; we’re back with another mega parlay, NFL edition. I’ve had a ton of success with these mega parlays, and even hit one at 74/1 in Week 13 last year.

Last week we came really close to hitting at 16/1, as we hit the Bengals +230 and the Giants +130, but we missed the final leg. We’re going big and bold again, so let’s not waste any more time. But before we dive in, don’t forget to check out our picks for the side and total on every NFL game.

Indianapolis Colts -2.5 (-115)

Pittsburgh Steelers ML (+180)

Jacksonville Jaguars ML (+164)

Parlay odds: +1282

Let’s break down each of the three legs one by one.

Indianapolis Colts -2.5 (-115) over Tennessee Titans

To start this mega parlay we’ve got the Colts on the spread. Indianapolis is a lot better than their record indicates, and they’re peaking at the right time for this pivotal AFC South showdown. They’ve won three of their last four games, and the only loss in that span came on the road in overtime against an elite Ravens team. Indy almost beat the Titans on the road in Week 3, and that was when they were at rock-bottom and dealing with a ton of injuries.

Now they’re getting healthier, as Carson Wentz’s ankles are back to normal and All-Pro guard Quenton Nelson has returned to the lineup. Wentz is playing arguably the best football of his career, and everything is starting to click for Frank Reich’s offense. Julio Jones is out for the Titans, and Indy has one of the best run defenses in the league so they should slow down Derrick Henry.

Be sure to check out our full game preview for Tennessee Titans vs Indianapolis Colts

Pittsburgh Steelers ML (+180) over Cleveland Browns

Let’s move on to our first money line underdog of this parlay. I think the Steelers are going to get revenge for their humiliating playoff loss last year. Pittsburgh has had this date circled ever since the schedule got announced, and they’re starting to play a lot better after a slow start. The Steelers have won back-to-back games, and Ben Roethlisberger is showing signs of life. Cleveland’s offense has been circling the drain lately, and they’ve scored 17 points or fewer in three of their past four.

With an injured and ineffective Baker Mayfield under center, I don’t expect them to eclipse that mark here. The last time Mayfield played, the Browns put up 14 points at home against Arizona in an ugly loss. But they really scored only seven points, since the other seven came on a fluke Hail Mary heave at the end of the first half.

Be sure to check out our full game preview for Pittsburgh Steelers vs Cleveland Browns

Jacksonville Jaguars ML (+164) over Seattle Seahawks

To wrap up this mega parlay, we’ll turn to the late afternoon slate. Call me crazy, but I like the Jaguars to get their second win in a row. Jacksonville picked up the first victory of the Urban Meyer era their last time out, and they were quietly getting better even before that. Their last three games prior to that win were against the Cardinals, Bengals and Titans, three of the hottest teams in the league. You can’t really fault them for losing those.

Trevor Lawrence is making major strides, and Seattle just had their hearts ripped out with back-to-back losses in primetime games. The Seahawks are now 2-5, and now know their season is over. I expect them to be demoralized with Geno Smith under center. They gave everything they had in those primetime games to try to save their season, and now they could come out flat.

Be sure to check out our full game preview for Jacksonville Jaguars vs Seattle Seahawks

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