Opening NFL Week 16 betting lines, odds and spreads in Early Birds with Jared Smith

Dak Prescott of the Dallas Cowboys
Photo of Jared Smith

Jared Smith


Show Bio

Jared Smith, a versatile host and analyst with over 10 years of experience in sports media and two decades as a sports bettor, has joined the Pickswise team as a lead betting analyst. Smith will serve as a full-time content creator, producing informative and engaging content every day across multiple platforms.

Week 16 of the NFL season is approaching, so it’s time to look ahead to the opening betting lines, odds and spreads. Our lead betting analyst Jared Smith and Twinspires Director of Retail Sports Zachary Lucas offer insights into the lines and early betting takeaways for this week’s games.

Buy Low: Titans vs Texans

We are buying the dip again with Tennessee. There are plenty of 7s available in the market at the time of publication after this line reopened at 7.5 following the Titans’ push against the Chargers. I honestly thought head coach Mike Vrabel was going to go for 2 on that final touchdown drive and get us off the 3, but Brandon Staley smartly used his timeouts — which gave Vrabel a more difficult decision after Ryan Tannehill scored in the final minute.

Meanwhile, Houston is coming off another hard-fought loss against a contender. Thus it’s fair to also call this a sell-high opportunity on a Texans team probably running on fumes. Derrick Henry torched Houston’s defense for 219 rush yards and 2 touchdowns back in Week 8, a game Tennessee won by a touchdown despite Malik Willis starting at quarterback. I expect the Titans to exceed that margin this week with Tannehill under center and perhaps Treylon Burks also returning from concussion.

Zachary’s prediction: I’m going with them  again. The Texans just played their Super Bowl vs the top team in the NFL and took them 12 rounds. The Titans should be able to dominate both sides of the ball.

Buy Low: Cowboys vs Eagles

This game lost a lot of its luster after the Cowboys collapsed in Jacksonville, but the Eagles also failed to meet oddsmaker expectations in Chicago so we aren’t getting a major discount on Dallas. Casual fans will likely look at this line and wonder why the 13-win Eagles aren’t favored, but the underlying metrics have been very high on Dallas this season despite Sunday’s result.

It’s hard to quantify the Cowboys mindset this week considering their NFC East hopes are all but dashed, but they can still ruin Christmas for their biggest rival — which should be motivation enough. Philly’s front also showed a big weakness trying to slow down the legs of Justin Fields, who rushed for nearly 100 yards and looked unstoppable at times.

Zachary’s prediction: Fields made it look easy even with a bad O-Line. The Cowboys’ offense should be able to drop 28+ on Philadelphia. The Cowboys’ D — while not that great — still has the capability of making plays. Dallas is a contrarian favorite.

Sell High: Jaguars at Jets

You can make a case for the Jets being a buy-low team, as well, but I think the stronger vibe is to sell the Jaguars off a miraculous comeback that climaxed with a fluky pick-6 in overtime. The Cowboys were gashing this Jacksonville defense for the first 40 minutes, but things just seemed to snowball towards the end of the 3rd quarter and the Jags were able to close the deal in the extra frame. Now they must refocus and travel north on a short week against a Jets team that has its back squarely against the wall after suffering its own gut punch on Sunday by blowing a late lead to the Lions.

Zach Wilson looked inconsistent at times but still showed flashes of brilliance and made enough plays to put his team in a position to win the game; instead, it was the defense and special teams that let the Jets down in the final minutes. It’s already being widely reported that Mike White will miss this game as he continues to recover from fractured ribs, so Wilson will get another start.

Zachary’s prediction: The Jets had that game and the Jags are feeling really good about themselves. Public perception at an all-time high for the Jags. I would jump on Jets +1.5 right now. The wrong team is favored.

Week 16 Early Birds

Titans -7
Cowboys -1.5
Jets +1.5

Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.

Virginia Bonuses

See All
FanDuel Sportsbook
Bet $5+ on Lions vs. Packers and Receive $200 in Bonus Bets!

Sign up for a new FanDuel Sportsbook account

Bet $5 on any sporting event

Receive $200 in Bonus Bets

Must be 21+. First online real money wager only. $10 first deposit required. Bonus issued as non-withdrawable free bets that expire 14 days after receipt. See full terms at Gambling problem? Call 1-800-GAMBLER. 21+
Bet $1 and Get $365 in Bonus Bets!

Register for a new bet365 account

Place qualifying bets of $1 or more

Get $365 in bonus bets - no matter if your bet wins or loses

Gambling problem? Call 1-800-GAMBLER. 21+. Physically present in OH, CO, NJ, VA, IA. Eligibility restrictions apply. Subject to regulatory licensing requirements. Opt-in req. Valid 1 per customer.
Bet $5 on Lions vs. Packers, Get $200 in Bonus Bets Instantly + Up to $150 in No Sweat Bets!

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Bet $5+ on any sports market and get $200 in bonus bets instantly

Plus up to $150 back in bonus bets if your team loses!

Gambling Problem? Call 877-8-HOPENY/text HOPENY (467369) (NY), If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (CO/IL/IN/LA/MD/MI/NJ/PA/TN/WV/WY), 1-800-NEXT STEP (AZ), 1-800-522-4700 (KS), 888-789-7777/visit (CT), 1-800-BETS OFF (IA), or 1-888-532-3500 (VA). 21+ (18+ WY). Physically present in AZ/CO/CT/IL/IN/IA/KS/LA(select parishes)/MD/MI/NJ/NY/PA/TN/VA/WV/WY only. Void in OH/ONT. Eligibility restrictions apply. Valid 1 per new customer. Min. $5 deposit. Min. $5 bet. $200 issued as bonus bets that expire 7 days (168 hours) after being awarded. See terms at
Caesars Sportsbook
$1,000 First Bet on Caesars for Lions vs. Packers!

Sign up for a new Caesars Sportsbook account and Place your 1st wager of $10 or more

Place your first wager of $50 or more and get $50 bonus bet upon settlement of your first wager

You will receive an additional $50 bonus bet each subsequent Monday

21+. New users and first wager only. Must register with eligible promo code. Bet amount of qualifying wager returned only if wager is settled as a loss. Min. bet $50; must be used within 14 days of receipt. See for full terms. Void where prohibited. Know When To Stop Before You Start.® Gambling problem? Call 1-800-GAMBLER
Get $1,500 Paid Back in Bonus Bets if you Don't Win Your First Bet on Lions vs. Packers!

Register for a new BetMGM account & deposit

Place your first bet up to $1,500!

Get refunded up to $1,500 in bonus bets if you don't win

Gambling problem? Call 1-800-GAMBLER CO, IL, IN, LA, MD, MS, NJ, OH, PA, TN, VA, WV, WY, MA 21+ to wager. Please Gamble Responsibly. Call 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS, NV), 1-800-BETS-OFF (IA), 1-800-270-7117 for confidential help (MI). Visit for Terms & Conditions. US promotional offers not available in DC, Nevada, New York or Ontario
Bet $50, Get $111 in Fred Bets + Up To $1,000 Back!

Sign up for a new account with Betfred Sports and make your first deposit

Place a $50 wager on any sport

Get $111 in Fred Bets + Up To $1,000 Back in Losses over 5 Week!

Must be 21+. T&Cs apply. Wagers only accepted in CO, AZ, IA, OH, VA, MD. Full terms available from Betfred Sports.
Get Up To $1,000 in Second Chance Bets!

Sign up for a new PointsBet account

If any of your first 10 cash bets lose (first bet per day for 10 days)

You will receive Bonus Bet(s) in the amount of the losing wager(s), up to $100 each.

Must be 21+. Full terms are available at PointsBet. Gambling problem? Call 1-800-GAMBLER. 21+. Physically present in. Eligibility restrictions apply. Subject to regulatory licensing requirements. Opt-in req. Valid 1 per customer.
Get up to $500 Back in Bonus Bets if your First Bet Doesn't Win

Sign up for a new BetRivers account using promo code SPORTS

Make your first deposit & and bet up to $500

If your first bet loses, get up to $500 back in bonus bets

Must be 21+. Gambling Problem? Call 1-800-BETS OFF
Get a $1,000 Deposit Bonus

Create a new DraftKings Sportsbook account and make your first deposit (min $5)

DraftKings will match 20% of your deposit up to $1,000 total

To get a $100 bonus, deposit $500

21+. Terms & conditions apply.
Underdog Fantasy
First deposit is 100% matched up to $500 with Underdog Fantasy!

Sign up for a new account with Underdog Fantasy

Make your first deposit

Every dollar (up to $500) will be matched! Deposit $25, get $50; deposit $100, get $200, etc

Must be 21+ to play. Terms & conditions apply
By signing up you agree to our terms and privacy policy