NFL Week 10 5-Leg Parlay: Best Picks for Sunday's Games at +1577 odds

Week 10 of the NFL season kicked off with the Commanders’ essential victory over the NFC East rival Giants, and now it’s time to focus on a full Sunday slate. It is headlined by Patriots vs Lions in Munich, Vikings vs Packers, 49ers vs Cowboys and Steelers vs Bengals on Sunday Night Football. 

If Luther Burden III had simply held on to the football late in the Bears’ win but non-cover against the Bucs, I would have cashed my +1696 mega parlay last week. Let’s try to get across the finish line with my Week 11 parlay below, and also be sure to check out all of our NFL picks.  

Lions -2.5 (-120) 

Chiefs -3 (-120) 

Texans ML (-235)  

Packers -2.5 (-120) 

Steelers +3.5 (-110)  

NFL parlay odds: +1577 

Lions -2.5 over Patriots (-120)  

Drake Maye has been all over the place for the Patriots this season. He has thrown multiple interceptions three times already, including three during last weekend’s blowout loss to Green Bay. In turn, Maye’s team has also been wildly erratic. New England fell to Jacksonville by 29 points, won four of its next five games and then got clobbered by Green Bay 45-27. It’s hard to have any faith in this club after what it put on tape against the Packers, with some disastrous developments on both offense and defense. The Pats watched Jordan Love complete 23 of 29 passes for 372 yards and three TDs. Now they have to go up against one of the best offenses in football, so I expect Jared Goff and Jahmyr Gibbs to have a day in front of the German fans in Munich. 

Chiefs -3 over Falcons (-120) 

Patrick Mahomes may not be entirely 100 percent, but he is good to go for Sunday’s date in Atlanta despite an elbow injury sustained last week. And even a less-than-100-percent Mahomes should be more than good enough to take care of a reeling Falcons outfit. He also has a new and much-needed receiver at his disposal after Kansas City traded for Josh Downs from Indianapolis prior to the deadline. The Falcons are coming off a long travel week, as they lost to Cincinnati in Madrid last Sunday. They have now dropped four of their last five games. There is no real home-field advantage in Atlanta, so K.C. should be giving more than three points. This spread is a steal. 

Texans ML over Browns (-235) 

Cleveland’s offense is not very good to begin with, and now it has six starters currently listed as questionable. The Browns also have five defensive starters listed as the same. Even at full strength, Cleveland is by no means as good of a team as Houston. The Texans have underwhelmed in 2026, but their talent – especially on defense – cannot be discounted. With CJ Stroud looking like his old self and Tank Dell finally back on the field, the visitors may be able to do enough offensively to support what will likely be a dominant defensive performance. I’m not overly inclined to give 4.5 points in a contest that is likely to be on the low-scoring side, but Houston should be able to win this one outright. 

Packers -2.5 over Vikings (-120) 

The Vikings would probably lose to anyone with Carson Wentz under center. With Kirk Cousins now on board, it’s a different story. However, Cousins’ first start with his new – and also former – team is tough one at Lambeau Field against the NFC North rival Packers. Even though the veteran knows Minnesota’s system, a very short week of practice is not exactly ideal. As such, this is a fantastic spot for the Packers – who are playing great football and should also benefit from home-field advantage. They have won five of their last six games and their only loss in the Frozen Tundra this season came back in Week 3 when their offensive line was in complete shambles. Love and company are a well-oiled machine at this point in time and should prevail by at least a field goal in this massive divisional matchup. 

Steelers +3.5 over Bengals (-110) 

I’m almost always willing to take more than field goal in any AFC North matchup, and this one on Sunday Night Football is no exception. Games in this division just always seem to be physical and competitive affairs, often decided by no more than three points. The Bengals’ offense is explosive, but asking them to comfortably beat an opponent to whom they have already lost this season (30-27 at Pittsburgh in Week 3) feels like a stretch. Even for Joe Burrow, this is not an easy matchup. The Steelers rank #4 league wide in both total defense and scoring defense, and they are #3 against the run. Cincy’s offense is going to be one-dimensional on Sunday – which is nothing new, of course. The Bengals might win straight up, but I will happily take 3.5 points.